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The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.
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Protein Aliases: FOG-2; Friend of GATA 2; Friend of GATA protein 2; friend of GATA-1 2; friend of GATA-2; Friend of GATA2; mFOG-2; transcription factor GATA4, modulator of; Zinc finger protein 89B; Zinc finger protein multitype 2; Zinc finger protein ZFPM2; zinc finger protein, multitype 2
Gene Aliases: B330005D23Rik; DIH3; FOG-2; FOG2; hFOG-2; SRXY9; ZC2HC11B; ZFPM2; ZNF89B
UniProt ID: (Human) Q8WW38, (Mouse) Q8CCH7
Entrez Gene ID: (Human) 23414, (Mouse) 22762, (Rat) 314930
Molecular Function: transcription cofactor
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