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Invitrogen
FOLR2 Monoclonal Antibody (OTI4G6)
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Application
FIGURE: 1 / 6
FOLR2 Antibody (MA5-26933) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a FOLR2 monoclonal antibody (Product # MA5-26933) at a dilution of 1:150.
Product Details
MA5-26933
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4G6
Immunogen
Human recombinant protein fragment corresponding to amino acids 20-221 of FOLR2 produced in E.coli
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723188
Target Information
FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FBP; Folate receptor 2; folate receptor 2 (fetal); Folate receptor beta; folate receptor, beta; Folate receptor, fetal/placental; folate-binding protein, fetal/placental; FR-beta; Placental folate-binding protein
Gene Aliases: BETA-HFR; FBP; FBP/PL-1; FOLR2; FR-BETA; FR-P3
UniProt ID: (Human) P14207
Entrez Gene ID: (Human) 2350
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