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Bioss

FOX C2 Polyclonal Antibody

View all (28) FOXC2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

Application

FIGURE: 1 / 1

FOX C2 Antibody (BS-8730R) in WB

Lane 1: Cerebellum lysates probed with FOX C2 Polyclonal Antibody, Unconjugated (bs-8730R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.

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Product Details

BS-8730R

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human FOX C2.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BF-3; Brain factor 3; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; HFH-BF-3; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14

Gene Aliases: Fkh14; FKHL14; FOXC2; Hfhbf3; LD; MFH-1; MFH1

UniProt ID: (Human) Q99958, (Rat) Q63246, (Mouse) Q61850

Entrez Gene ID: (Human) 2303, (Rat) 171356, (Mouse) 14234

Function(s)

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding chromatin DNA binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding winged helix/forkhead transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter ossification patterning of blood vessels metanephros development ureteric bud development somitogenesis lymphangiogenesis blood vessel remodeling transcription from RNA polymerase II promoter Notch signaling pathway mesoderm development heart development insulin receptor signaling pathway response to hormone positive regulation of endothelial cell migration neural crest cell development collagen fibril organization positive regulation of cell adhesion mediated by integrin embryonic heart tube development positive regulation of vascular wound healing camera-type eye development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesodermal cell fate commitment embryonic viscerocranium morphogenesis artery morphogenesis regulation of blood vessel size ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis negative regulation of apoptotic process involved in outflow tract morphogenesis skeletal system development blood vessel development kidney development lymph vessel development heart morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell proliferation paraxial mesoderm formation embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis transcription, DNA-templated multicellular organism development positive regulation of integrin activation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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