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Proteintech

FOXA1 Polyclonal Antibody

9 References

View all (50) FOXA1 antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (17)

Application

FOXA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 17

FOXA1 Antibody (20411-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using (Product # 20411-1-AP) (FOXA1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

20411-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FOXA1 Fusion Protein Ag14243 (267-399 aa encoded by BC033890)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KCEKQPGAG GGGGSGSGGS GAKGGPESRK DPSGASNPSA DSPLHRGVHG KTGQLEGAPA PGPAASPQTL DHSGATATGG ASELKTPASS TAPPISSGPG ALASVPASHP AHGLAPHESQ LHLKGDPHYS FNHP (267-399 aa encoded by B C033890)

Target Information

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Epithelial cells activate fibroblasts to promote esophageal cancer development.

Cancer cell

Chen Y,Zhu S,Liu T,Zhang S,Lu J,Fan W,Lin L,Xiang T,Yang J,Zhao X,Xi Y,Ma Y,Cheng G,Lin D,Wu C

Mon May 08 00:00:00 UTC 2023

FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.

Scientific reports

Czerny CC,Borschel A,Cai M,Otto M,Hoyer-Fender S

Mon Dec 12 00:00:00 UTC 2022

FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.

Scientific reports

Czerny CC,Borschel A,Cai M,Otto M,Hoyer-Fender S

Mon Dec 12 00:00:00 UTC 2022

A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.

Journal of experimental & clinical cancer research : CR

Liu W,Ren D,Xiong W,Jin X,Zhu L

Wed Jan 26 00:00:00 UTC 2022

Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathway.

Stem cell research & therapy

Li L,Wang Y,Wang Z,Xue D,Dai C,Gao X,Ma J,Hang K,Pan Z

Mon Sep 05 00:00:00 UTC 2022

An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.

Cancer letters

Xie Z,Wang F,Lin L,Duan S,Liu X,Li X,Li T,Xue M,Cheng Y,Ren H,Zhu Y

Mon Dec 28 00:00:00 UTC 2020

Upregulated forkhead-box A3 elevates the expression of forkhead-box A1 and forkhead-box A2 to promote metastasis in esophageal cancer.

Oncology letters

Chen B,Yu J,Lu L,Dong F,Zhou F,Tao X,Sun E

Wed May 01 00:00:00 UTC 2019

Down-regulation of TRPS1 stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1.

The Journal of pathology

Huang JZ,Chen M,Zeng M,Xu SH,Zou FY,Chen D,Yan GR

Wed Jun 01 00:00:00 UTC 2016

miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.

Oncotarget

Zhu X,Li D,Yu F,Jia C,Xie J,Ma Y,Fan S,Cai H,Luo Q,Lv Z,Fan L

Tue Mar 15 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Ci-fkh; fkd7; fkh; Forkhead box protein A1; forkhead-7; FoxA4a; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; tFoxA1; Transcription factor 3A; xfkh1; xfkh2

Gene Aliases: FOXA1; HNF3A; TCF3A

UniProt ID: (Human) P55317

Entrez Gene ID: (Human) 3169

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding sequence-specific DNA binding transcription regulatory region DNA binding winged helix/forkhead transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter chromatin remodeling transcription from RNA polymerase II promoter Notch signaling pathway negative regulation of epithelial to mesenchymal transition covalent chromatin modification dorsal/ventral neural tube patterning response to estradiol positive regulation of intracellular estrogen receptor signaling pathway hormone metabolic process glucose homeostasis positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis neuron fate specification positive regulation of sequence-specific DNA binding transcription factor activity epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development epithelial-mesenchymal signaling involved in prostate gland development prostate gland epithelium morphogenesis prostate gland stromal morphogenesis epithelial cell maturation involved in prostate gland development alveolar secondary septum development dopaminergic neuron differentiation respiratory basal cell differentiation positive regulation of cell-cell adhesion mediated by cadherin

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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