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Proteintech

FOXC1 Polyclonal Antibody

3 References

View all (14) FOXC1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (6)

Application

FIGURE: 1 / 6

FOXC1 Antibody (55365-1-AP) in WB

HEK-293 cells were subjected to SDS PAGE followed by western blot with 55365-1-AP (FOXC1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

FOXC1 Antibody in Immunoprecipitation (IP)

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Product Details

55365-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated

Form

Liquid

Concentration

0.74 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to FOXC1. Phosphorylation modification of Foxc1 protein may be responsible for the larger molecular weight of detection compared with theoretical molecular weight.

Target Information

FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The osteoporosis risk variant rs9820407 at 3p22.1 acts as an allele-specific enhancer to regulate CTNNB1 expression by long-range chromatin loop formation.

Bone

Wang Y,Lu L,Niu Y,Zhang Q,Cheng C,Huang H,Huang X,Huang Q

Wed Dec 01 00:00:00 UTC 2021

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling.

Molecular medicine reports

Cao Q,Wang X,Shi Y,Zhang M,Yang J,Dong M,Mi Y,Zhang Z,Liu K,Jiang L,Wang N,Wang P

Tue Jan 01 00:00:00 UTC 2019

The long noncoding RNA FOXCUT promotes proliferation and migration by targeting FOXC1 in nasopharyngeal carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Xu YZ,Chen FF,Zhang Y,Zhao QF,Guan XL,Wang HY,Li A,Lv X,Song SS,Zhou Y,Li XJ

Thu Jun 01 00:00:00 UTC 2017

The long noncoding RNA FOXCUT promotes proliferation and migration by targeting FOXC1 in nasopharyngeal carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Xu YZ,Chen FF,Zhang Y,Zhao QF,Guan XL,Wang HY,Li A,Lv X,Song SS,Zhou Y,Li XJ

Thu Jun 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: congenital hydrocephalus; forkhead box C1 protein; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FREAC-3; HGNC:3800; Mesoderm/mesenchyme forkhead 1; MF-1; myeloid factor-delta; Transcription factor FKH-1

Gene Aliases: ARA; ch; fkh-1; Fkh1; FKHL7; FOXC1; FREAC-3; FREAC3; frkhda; IGDA; IHG1; IRID1; Mf1; Mf4; RIEG3

UniProt ID: (Human) Q12948, (Mouse) Q61572

Entrez Gene ID: (Human) 2296, (Mouse) 17300

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding DNA binding, bending sequence-specific DNA binding transcription regulatory region DNA binding winged helix/forkhead transcription factor

Process(es)

skeletal system development ossification ovarian follicle development eye development ureteric bud development in utero embryonic development somitogenesis lymph vessel development blood vessel remodeling regulation of transcription, DNA-templated transcription from RNA polymerase II promoter Notch signaling pathway brain development heart development cell proliferation germ cell migration mesenchymal cell development neural crest cell development cell migration negative regulation of angiogenesis collagen fibril organization glycosaminoglycan metabolic process lacrimal gland development embryonic heart tube development maintenance of lens transparency vascular endothelial growth factor signaling pathway odontogenesis of dentin-containing tooth camera-type eye development positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation artery morphogenesis regulation of blood vessel size ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation negative regulation of lymphangiogenesis positive regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell differentiation negative regulation of apoptotic process involved in outflow tract morphogenesis blood vessel development kidney development heart morphogenesis transcription, DNA-templated positive regulation of gene expression mesenchymal cell differentiation

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FOXC1 Polyclonal Antibody

FOXC1 Antibody (55365-1-AP) in WB

Product Details

55365-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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