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Invitrogen

FOXH1 Polyclonal Antibody

View all (10) FOXH1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

Application

FIGURE: 1 / 1

FOXH1 Antibody (PA5-41472) in WB

Western blot analysis of human HT1080 cell lysate using an anti-FOXH1 polyclonal antibody (Product # PA5-41472).

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Product Details

PA5-41472

Applications

Tested Dilution

Publications

Western Blot (WB)

0.2-1 µg/mL

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N-terminal of human FOXH1 (aa 1-50).

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2610034

Product Specific Information

Peptide sequence: MGPCSGSRLG PPEAESPSQP PKRRKKRYLR HDKPPYTYLA MIALVIQAAP

Sequence homology: Cow: 86%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Pig: 83%; Rabbit: 79%; Rat: 79%

Target Information

FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fast-1; Fast-2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; forkhead activin signal transducer-1; Forkhead box protein H1; hFAST-1; TGF-beta/activin signal transducer

Gene Aliases: FAST-1; FAST1; FAST2; FOXH1

UniProt ID: (Human) O75593

Entrez Gene ID: (Human) 8928

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription cofactor activity transcriptional activator activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding enhancer binding bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding SMAD binding androgen receptor binding co-SMAD binding R-SMAD binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter heart looping secondary heart field specification outflow tract morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway negative regulation of intracellular estrogen receptor signaling pathway embryonic heart tube anterior/posterior pattern specification aorta morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter axial mesoderm development negative regulation of androgen receptor signaling pathway nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of androgen receptor activity

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