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Invitrogen
FOXO1/FOXO3/FOXO4 Polyclonal Antibody
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Application
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FOXO1/FOXO3/FOXO4 Antibody (PA5-116792) in IHC (P)
Immunohistochemistry analysis of FOXO1/FOXO3/FOXO4 in paraffin-embedded human placenta. Samples were incubated with FOXO1/FOXO3/FOXO4 Polyclonal antibody (Product # PA5-116792) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-116792
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide of human FOXO1/FOXO3A/FOXO4 (NP_0020062)
Conjugate
Unconjugated
Form
Liquid
Concentration
1.34 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901423
Product Specific Information
Positive Samples: 293T, HeLa, Mouse liver, Mouse skeletal muscle, Mouse lung, Rat liver
Target Information
FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AF6q21 protein; Afxh; Fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; FOXO1; FOXO1A; FOXO2; FOXO3; FOXO3A; FOXO4; MLLT7; RGD1561201
UniProt ID: (Human) Q12778, (Human) O43524, (Human) P98177, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH4, (Mouse) Q9WVH3
Entrez Gene ID: (Human) 2308, (Human) 2309, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Mouse) 56484, (Rat) 294515, (Rat) 302415, (Mouse) 54601
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