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Invitrogen

FOXP3 Monoclonal Antibody (FJK-16s), PE-Cyanine5, eBioscience™

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97 Published Figures

214 References

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Catalog # 15-5773-82

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Datasheet

Protocols

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Application

FIGURE: 1 / 99

FOXP3 Antibody (15-5773-82) in Flow

Mouse (BALB/c) splenocytes were surface-stained with Anti-Mouse CD4 FITC (Product # 11-0041-82) and Anti-Mouse CD25 PE (Product # 12-0251-82), and subsequently with Anti-Mouse/Rat Foxp3 PE-Cyanine5 or Rat IgG2a Isotype Control PE-Cyanine5 (Product # 15-4321-80) using the Foxp3/Transcription Factor Buffer Set (Product # 00-5523-00).The dot plot on the left demonstrates co-staining of CD4 and FJK-16s, while the right plot demonstrates co-staining of CD25 and FJK-16s.Cells in the lymphocyte gate were used for analysis.

Product Image Gallery

FOXP3 Antibody — Intracellular staining of mouse splenocytes. As expected based on known relative expression patterns, Foxp3 clone FJK-16s stains a subset of the CD4+ T cells and does not stain the CD8+ T cells. Details: Balb/c splenocytes were surface stained with CD3 (clone 17A2), CD4 (clone GK1.5) and CD8 (clone 53-6.7), followed by intracellular staining with Foxp3 (clone FJK-16s) using the Foxp3/Transcription Factor Staining Buffer Set and protocol. Lymphocytes in the CD3+CD8+ (blue histogram) and CD3+CD4+ (purple histogram) gates were used for analysis. {RE}

Product Details

15-5773-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1 µg/test

View 214 publications 214 publications

Product Specifications

Species Reactivity

Bovine, Dog, Cat, Mouse, Pig, Rat

Published species

Bovine, Hamster, Mouse, Rat

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

FJK-16s

Conjugate

PE-Cyanine5

Excitation/Emission Max

568/666 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_468806

Product Specific Information

Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.

Applications Reported: This FJK-16s antibody has been reported for use in intracellular flow cytometric analysis.

Applications Tested: This FJK-16s antibody has been tested by intracellular staining and flow cytometric analysis of mouse splenocytes using the Foxp3/Transcription Factor Buffer Set (Product # 00-5523-00) and protocol. Please see BestProtocols® Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). This antibody can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.

Nature immunology

Linnerbauer M,Lößlein L,Vandrey O,Peter A,Han Y,Tsaktanis T,Wogram E,Needhamsen M,Kular L,Nagel L,Zissler J,Andert M,Meszaros L,Hanspach J,Zuber F,Naumann UJ,Diebold M,Wheeler MA,Beyer T,Nirschl L,Cirac A,Laun FB,Günther C,Winkler J,Bäuerle T,Jagodic M,Hemmer B,Prinz M,Quintana FJ,Rothhammer V

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 01 00:00:00 UTC 2024

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4⁺ T cells.

Frontiers in immunology

Sandoval S,Malany K,Thongphanh K,Martinez CA,Goodson ML,Souza FDC,Lin LW,Sweeney N,Pennington J,Lein PJ,Kerkvliet NI,Ehrlich AK

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Dec 05 00:00:00 UTC 2023

Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.

ImmunoHorizons

Arwood ML,Sun IH,Patel CH,Sun IM,Oh MH,Bettencourt IA,Claiborne MD,Chan-Li Y,Zhao L,Waickman AT,Mavrothalassitis O,Wen J,Aja S,Powell JD

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Jun 01 00:00:00 UTC 2023

Resolvin D1 promotes the resolution of inflammation in the ACLF rat model by increasing the proportion of Treg cells.

Immunity, inflammation and disease

Chen L,Huang Y,Chen Y,Chen J,You X,Zou L,Chen J,Chen Z,Wang X,Huang Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Nov 01 00:00:00 UTC 2023

An essential role for miR-15/16 in Treg suppression and restriction of proliferation.

Cell reports

Johansson K,Gagnon JD,Zhou SK,Fassett MS,Schroeder AW,Kageyama R,Bautista RA,Pham H,Woodruff PG,Ansel KM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 31 00:00:00 UTC 2023

Chronic hypoxia disrupts T regulatory cell phenotype contributing to the emergence of exTreg-T_H17 cells.

Frontiers in physiology

Lantz BJ,Moriwaki M,Oyebamiji OM,Guo Y,Gonzalez Bosc L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Dec 14 00:00:00 UTC 2024

A phase I, first-in-human study to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of MRG-001 in healthy subjects.

Cell reports. Medicine

Ahmadi AR,Atiee G,Chapman B,Reynolds L,Sun J,Cameron AM,Wesson RN,Burdick JF,Sun Z

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Sep 19 00:00:00 UTC 2023

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity.

International journal of inflammation

Bourebaba L,Serwotka-Suszczak A,Bourebaba N,Zyzak M,Marycz K

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 10 00:00:00 UTC 2023

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation.

Investigative ophthalmology & visual science

Lee JY,Kim S,Sohn HJ,Kim CH,Kim TG,Lee HS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 03 00:00:00 UTC 2023

Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.

Chinese medicine

Pu S,Yang Z,Zhang X,Li M,Han N,Yang X,He J,Yu G,Meng X,Jia Q,Shao H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Oct 12 00:00:00 UTC 2023

Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats.

Journal of cardiovascular development and disease

Jang S,Kim JY,Kim CW,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Oct 02 00:00:00 UTC 2023

Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the myocardium of mice after myocardial infarction.

Phytotherapy research : PTR

Tian CX,Li MY,Shuai XX,Jiang F,Dong YL,Gui Y,Zhang ZL,Qin RJ,Kang ZY,Lin L,Sarapultsev A,Wu B,Luo SS,Hu DS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Jan 01 00:00:00 UTC 2023

Tumor-specific cholinergic CD4⁺ T lymphocytes guide immunosurveillance of hepatocellular carcinoma.

Nature cancer

Zheng C,Snow BE,Elia AJ,Nechanitzky R,Dominguez-Brauer C,Liu S,Tong Y,Cox MA,Focaccia E,Wakeham AC,Haight J,Tobin C,Hodgson K,Gill KT,Ma W,Berger T,Heikenwälder M,Saunders ME,Fortin J,Leung SY,Mak TW

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Oct 01 00:00:00 UTC 2023

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.

Nature communications

Linnerbauer M,Beyer T,Nirschl L,Farrenkopf D,Lößlein L,Vandrey O,Peter A,Tsaktanis T,Kebir H,Laplaud D,Oellinger R,Engleitner T,Alvarez JI,Rad R,Korn T,Hemmer B,Quintana FJ,Rothhammer V

15-5773-82 was used in Flow cytometry/Cell sorting to suggest the glial PD-L1/PD-1 axis as a potential therapeutic target for both acute and progressive MS stages.

Sat Sep 09 00:00:00 UTC 2023

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.

Nature communications

Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 24 00:00:00 UTC 2023

Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

Frontiers in immunology

Schwarz A,Philippsen R,Piticchio SG,Hartmann JN,Häsler R,Rose-John S,Schwarz T

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Mar 27 00:00:00 UTC 2023

SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.

Cell communication and signaling : CCS

Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Mar 02 00:00:00 UTC 2023

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma.

The Journal of experimental medicine

Reijers ILM,Rao D,Versluis JM,Menzies AM,Dimitriadis P,Wouters MW,Spillane AJ,Klop WMC,Broeks A,Bosch LJW,Lopez-Yurda M,van Houdt WJ,Rawson RV,Grijpink-Ongering LG,Gonzalez M,Cornelissen S,Bouwman J,Sanders J,Plasmeijer E,Elshot YS,Scolyer RA,van de Wiel BA,Peeper DS,van Akkooi ACJ,Long GV,Blank CU

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon May 01 00:00:00 UTC 2023

Multiparametric flow cytometry to characterize vaccine-induced polyfunctional T cell responses and T cell/NK cell exhaustion and memory phenotypes in mouse immuno-oncology models.

Frontiers in immunology

Moi D,Zeng B,Minnie SA,Bhatt R,Wood J,Sester DP,Mazzieri R,Dolcetti R

15-5773-82 was used in Flow cytometry/Cell sorting to report the development and application of two 21-color flow cytometry panels allowing a comprehensive characterization of T cell and natural killer cell exhaustion and memory phenotypes in mice with a particular focus on preclinical cancer models.

Tue Apr 25 00:00:00 UTC 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Feb 13 00:00:00 UTC 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Mar 01 00:00:00 UTC 2023

Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity.

Nature communications

Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 24 00:00:00 UTC 2023

Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.

Cell research

Zhou C,Ma L,Xu H,Huo Y,Luo J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Jun 01 00:00:00 UTC 2022

miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg.

Molecular biology reports

Zou Q,Liu C,Hu N,Wang W,Wang H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Apr 01 00:00:00 UTC 2022

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.

Cancer cell

Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Oct 10 00:00:00 UTC 2022

Twelve-week high-fat diet for improving adverse ventricular remodeling post-myocardial infarction by alleviating local inflammation.

Annals of translational medicine

Yang J,Mai B,Su Y,Liang S,Su Z,Chen Y,Xie S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Oct 01 00:00:00 UTC 2022

Protocol to assess cell-intrinsic regulatory mechanisms using an ex vivo murine T cell polarization and co-culture system.

STAR protocols

Ma S,Hernandez JE,Huang WJM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Sep 16 00:00:00 UTC 2022

Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.

Cancers

Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Aug 31 00:00:00 UTC 2022

Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.

EMBO reports

Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Dec 06 00:00:00 UTC 2022

Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.

JCI insight

Klaus T,Wilson AS,Vicari E,Hadaschik E,Klein M,Helbich SSC,Kamenjarin N,Hodapp K,Schunke J,Haist M,Butsch F,Probst HC,Enk AH,Mahnke K,Waisman A,Bednarczyk M,Bros M,Bopp T,Grabbe S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Dec 22 00:00:00 UTC 2022

Pharmacologic Tumor PDL1 Depletion with Cefepime or Ceftazidime Promotes DNA Damage and Sensitivity to DNA-Damaging Agents.

International journal of molecular sciences

Murray C,Galvan E,Ontiveros C,Deng Y,Bai H,Padron AS,Hinchee-Rodriguez K,Garcia MG,Kornepati A,Conejo-Garcia J,Curiel TJ

15-5773-82 was used in Flow cytometry/Cell sorting to highlight the rapidly translated potential for PDL1-depleting drugs to inhibit tumor-intrinsic PDL1 signals and improve DNA-damaging agents and immunotherapy efficacy.

Wed May 04 00:00:00 UTC 2022

Galectin-9 Mediates the Therapeutic Effect of Mesenchymal Stem Cells on Experimental Endotoxemia.

Frontiers in cell and developmental biology

Zhao Y,Yu D,Wang H,Jin W,Li X,Hu Y,Qin Y,Kong D,Li G,Ellen A,Wang H

15-5773-82 was used in Flow cytometry/Cell sorting to reveal that the optimized immunoregulatory effect of MSCs is strongly correlated with Gal-9 high expression, which provides a novel idea for the investigation of MSC immunomodulatory mechanisms and offers a potential strategy for the treatment of endotoxemia in clinical settings.

Wed Mar 09 00:00:00 UTC 2022

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.

Immunity

Harb H,Benamar M,Lai PS,Contini P,Griffith JW,Crestani E,Schmitz-Abe K,Chen Q,Fong J,Marri L,Filaci G,Del Zotto G,Pishesha N,Kolifrath S,Broggi A,Ghosh S,Gelmez MY,Oktelik FB,Cetin EA,Kiykim A,Kose M,Wang Z,Cui Y,Yu XG,Li JZ,Berra L,Stephen-Victor E,Charbonnier LM,Zanoni I,Ploegh H,Deniz G,De Palma R,Chatila TA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jun 08 00:00:00 UTC 2021

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.

The Journal of experimental medicine

Wirasinha RC,Davies AR,Srivastava M,Sheridan JM,Sng XYX,Delmonte OM,Dobbs K,Loh KL,Miosge LA,Lee CE,Chand R,Chan A,Yap JY,Keller MD,Chen K,Rossjohn J,La Gruta NL,Vinuesa CG,Reid HH,Lionakis MS,Notarangelo LD,Gray DHD,Goodnow CC,Cook MC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Feb 01 00:00:00 UTC 2021

Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells.

Genes & diseases

Yang L,Jing Y,Kang D,Jiang P,Li N,Zhou X,Chen Y,Westerberg LS,Liu C

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat May 01 00:00:00 UTC 2021

Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone.

Immunology

Thomas R,Oh J,Wang W,Su DM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Aug 01 00:00:00 UTC 2021

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.

Cancer immunology, immunotherapy : CII

Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Jan 01 00:00:00 UTC 2021

Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.

Frontiers in cell and developmental biology

Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Apr 21 00:00:00 UTC 2021

Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.

BioMed research international

Kim JY,Lee E,Koo S,Kim CW,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue May 25 00:00:00 UTC 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Apr 01 00:00:00 UTC 2021

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.

Theranostics

Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Aug 04 00:00:00 UTC 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Oct 27 00:00:00 UTC 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Oct 29 00:00:00 UTC 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Jan 30 00:00:00 UTC 2021

Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.

Nature immunology

Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Sep 01 00:00:00 UTC 2021

ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.

Cell reports

Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Nov 23 00:00:00 UTC 2021

Dual Role of Interleukin-10 in Murine NZB/W F1 Lupus.

International journal of molecular sciences

Amend A,Wickli N,Schäfer AL,Sprenger DTL,Manz RA,Voll RE,Chevalier N

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Jan 29 00:00:00 UTC 2021

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.

Science advances

Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat May 01 00:00:00 UTC 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Jan 28 00:00:00 UTC 2022

Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots.

Frontiers in immunology

Furesi G,Fert I,Beaufrère M,Araujo LM,Glatigny S,Baschant U,von Bonin M,Hofbauer LC,Horwood NJ,Breban M,Rauner M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Oct 25 00:00:00 UTC 2021

A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.

Frontiers in immunology

Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW

15-5773-82 was used in Flow Cytometry to report that as with Mef2d, the deletion of Mef2c in Tregs switches off the expression of Il10 and Icos and leads to enhanced antitumor immunity in syngeneic models of lung cancer.

Fri Dec 17 00:00:00 UTC 2021

Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.

Frontiers in immunology

Linnerbauer M,Lößlein L,Farrenkopf D,Vandrey O,Tsaktanis T,Naumann U,Rothhammer V

15-5773-82 was used in Flow Cytometry to demonstrate in vivo that astrocyte-derived pleiotrophin is critical for the recovery phase of autoimmune encephalomyelitis and limits chronic CNS inflammation.

Mon Feb 14 00:00:00 UTC 2022

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jul 05 00:00:00 UTC 2021

Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.

Gastroenterology

Molina-Sánchez P,Ruiz de Galarreta M,Yao MA,Lindblad KE,Bresnahan E,Bitterman E,Martin TC,Rubenstein T,Nie K,Golas J,Choudhary S,Bárcena-Varela M,Elmas A,Miguela V,Ding Y,Kan Z,Grinspan LT,Huang KL,Parsons RE,Shields DJ,Rollins RA,Lujambio A

15-5773 was used in Flow cytometry/Cell sorting to establish a novel collection of hepatocellular carcinoma mouse models that captured human hepatocellular carcinoma diversity.

Tue Dec 01 00:00:00 UTC 2020

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.

Nature immunology

Harb H,Stephen-Victor E,Crestani E,Benamar M,Massoud A,Cui Y,Charbonnier LM,Arbag S,Baris S,Cunnigham A,Leyva-Castillo JM,Geha RS,Mousavi AJ,Guennewig B,Schmitz-Abe K,Sioutas C,Phipatanakul W,Chatila TA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Nov 01 00:00:00 UTC 2020

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

The Journal of clinical investigation

Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Apr 01 00:00:00 UTC 2020

MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.

The Journal of clinical investigation

Di Giorgio E,Wang L,Xiong Y,Akimova T,Christensen LM,Han R,Samanta A,Trevisanut M,Bhatti TR,Beier UH,Hancock WW

15-5773 was used in Flow cytometry/Cell sorting to study the role played by MEF2D in sustaining effector Foxp3+ Treg functions without abrogating their basal actions suggests its suitability for drug discovery efforts in cancer therapy.

Tue Dec 01 00:00:00 UTC 2020

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.

Immunology

Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Feb 01 00:00:00 UTC 2020

Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.

Acta pharmacologica Sinica

Son SE,Park SJ,Koh JM,Im DS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Oct 01 00:00:00 UTC 2020

Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats.

Disease models & mechanisms

Lee E,Kim N,Kang J,Yoon S,Lee HA,Jung H,Kim SH,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed May 27 00:00:00 UTC 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Jan 01 00:00:00 UTC 2020

A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.

Journal of cellular and molecular medicine

Li P,Wang J,Guo F,Zheng B,Zhang X

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Mar 01 00:00:00 UTC 2020

A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Gniadek TJ,Augustin L,Schottel J,Leonard A,Saltzman D,Greeno E,Batist G

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Sep 01 00:00:00 UTC 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Sep 28 00:00:00 UTC 2020

Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d^-/- Mice Lacking NKT Cells.

Integrative cancer therapies

Takaku S,Shimizu M,Takahashi H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Mar 23 00:00:00 UTC 2020

Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro.

Veterinary ophthalmology

Saldinger LK,Nelson SG,Bellone RR,Lassaline M,Mack M,Walker NJ,Borjesson DL

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Jan 01 00:00:00 UTC 2020

Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103⁺CD11b⁺ Dendritic Cells.

Frontiers in immunology

Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Apr 19 00:00:00 UTC 2021

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

Cell reports

Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 27 00:00:00 UTC 2020

Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3⁺ Treg Cells by Multiparameter Flow Cytometry.

STAR protocols

Li C,Park JH

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Dec 18 00:00:00 UTC 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jan 21 00:00:00 UTC 2020

FOXD3 Regulates VISTA Expression in Melanoma.

Cell reports

Rosenbaum SR,Knecht M,Mollaee M,Zhong Z,Erkes DA,McCue PA,Chervoneva I,Berger AC,Lo JA,Fisher DE,Gershenwald JE,Davies MA,Purwin TJ,Aplin AE

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jan 14 00:00:00 UTC 2020

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy.

Nature communications

Baumann D,Hägele T,Mochayedi J,Drebant J,Vent C,Blobner S,Noll JH,Nickel I,Schumacher C,Boos SL,Daniel AS,Wendler S,Volkmar M,Strobel O,Offringa R

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri May 01 00:00:00 UTC 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Mar 24 00:00:00 UTC 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Mar 24 00:00:00 UTC 2020

Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.

Scientific reports

Wang L,Wang Z,Han R,Samanta A,Ge G,Levin LS,Levine MH,Hancock WW

15-5773 was used in Flow cytometry/Cell sorting to tested whether peri-transplant costimulation blockade could prolong VCA survival and required donor bone-marrow cells, given that bone-marrow might promote graft immunogenicity or graft-versus-host disease.

Tue Jun 09 00:00:00 UTC 2020

Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.

Scientific reports

Wang L,Wang Z,Han R,Samanta A,Ge G,Levin LS,Levine MH,Hancock WW

Tue Jun 09 00:00:00 UTC 2020

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Research

Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Feb 01 00:00:00 UTC 2021

Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.

Medical science monitor : international medical journal of experimental and clinical research

Jin L,Hu Q,Hu Y,Chen Z,Liao W

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Dec 02 00:00:00 UTC 2020

Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.

PloS one

Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jul 06 00:00:00 UTC 2020

3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models.

Scientific reports

Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 27 00:00:00 UTC 2020

Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury.

Aging

Luo Y,Wang B,Liu J,Ma F,Luo D,Zheng Z,Lu Q,Zhou W,Zheng Y,Zhang C,Wang Q,Sha W,Chen H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Dec 03 00:00:00 UTC 2020

Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.

Biomedicines

Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Dec 16 00:00:00 UTC 2020

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.

Nature communications

Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Aug 11 00:00:00 UTC 2020

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.

Science advances

Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri May 01 00:00:00 UTC 2020

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Sep 28 00:00:00 UTC 2020

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Sep 28 00:00:00 UTC 2020

Compartmentalized gut lymph node drainage dictates adaptive immune responses.

Nature

Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed May 01 00:00:00 UTC 2019

Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.

Cell research

Zhang Y,Du X,Liu M,Tang F,Zhang P,Ai C,Fields JK,Sundberg EJ,Latinovic OS,Devenport M,Zheng P,Liu Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Aug 01 00:00:00 UTC 2019

Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice.

American journal of physiology. Lung cellular and molecular physiology

Shrestha AK,Bettini ML,Menon RT,Gopal VYN,Huang S,Edwards DP,Pammi M,Barrios R,Shivanna B

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jan 01 00:00:00 UTC 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jan 01 00:00:00 UTC 2019

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jun 11 00:00:00 UTC 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 01 00:00:00 UTC 2019

Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.

Frontiers in immunology

Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Nov 17 00:00:00 UTC 2020

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Oct 14 00:00:00 UTC 2020

Loss of TET2 and TET3 in regulatory T cells unleashes effector function.

Nature communications

Yue X,Lio CJ,Samaniego-Castruita D,Li X,Rao A

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed May 01 00:00:00 UTC 2019

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.

Nature communications

Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue May 14 00:00:00 UTC 2019

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

Nature communications

Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Oct 28 00:00:00 UTC 2019

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.

Scientific reports

Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Dec 11 00:00:00 UTC 2019

A20 as an immune tolerance factor can determine islet transplant outcomes.

JCI insight

Zammit NW,Walters SN,Seeberger KL,O'Connell PJ,Korbutt GS,Grey ST

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Nov 01 00:00:00 UTC 2019

Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.

Scientific reports

Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Apr 25 00:00:00 UTC 2019

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.

Cell reports

Fu Z,Ye J,Dean JW,Bostick JW,Weinberg SE,Xiong L,Oliff KN,Chen ZE,Avram D,Chandel NS,Zhou L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jul 02 00:00:00 UTC 2019

Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.

Cell reports

Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG

15-5773-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.

Tue Dec 03 00:00:00 UTC 2019

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Jun 28 00:00:00 UTC 2018

Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.

Immunity

Grizotte-Lake M,Zhong G,Duncan K,Kirkwood J,Iyer N,Smolenski I,Isoherranen N,Vaishnava S

15-5773 was used in Flow cytometry/Cell sorting to define a regulatory circuit wherein bacterial regulation of IEC-intrinsic RA synthesis protects microbial communities in the gut from excessive immune activity, achieving a balance that prevents colonization by enteric pathogens.

Tue Dec 18 00:00:00 UTC 2018

PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.

The Journal of clinical investigation

Kraakman MJ,Liu Q,Postigo-Fernandez J,Ji R,Kon N,Larrea D,Namwanje M,Fan L,Chan M,Area-Gomez E,Fu W,Creusot RJ,Qiang L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Jun 01 00:00:00 UTC 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jul 02 00:00:00 UTC 2018

MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.

Autophagy

Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 22 00:00:00 UTC 2019

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Apr 04 00:00:00 UTC 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Feb 27 00:00:00 UTC 2018

Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.

British journal of pharmacology

Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Apr 01 00:00:00 UTC 2018

Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.

Frontiers in immunology

Stanisavljević S,Dinić M,Jevtić B,Đedović N,Momčilović M,Đokić J,Golić N,Mostarica Stojković M,Miljković Đ

15-5773 was used in Flow cytometry/Cell sorting to study the effects of modulating the gut microbiota of albino oxford rats using antibiotics.

Mon Jul 01 00:00:00 UTC 2019

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis.

Frontiers in immunology

LaMothe RA,Kolte PN,Vo T,Ferrari JD,Gelsinger TC,Wong J,Chan VT,Ahmed S,Srinivasan A,Deitemeyer P,Maldonado RA,Kishimoto TK

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Mar 21 00:00:00 UTC 2019

CD4⁺ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Frontiers in immunology

Cobbold SP,Adams E,Howie D,Waldmann H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jan 31 00:00:00 UTC 2022

Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Immunology

Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Jul 01 00:00:00 UTC 2018

TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Sep 26 00:00:00 UTC 2018

PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani.

Infection and immunity

Habib S,El Andaloussi A,Elmasry K,Handoussa A,Azab M,Elsawey A,Al-Hendy A,Ismail N

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Jun 01 00:00:00 UTC 2018

Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.

Oncology letters

Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Sep 01 00:00:00 UTC 2018

Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.

Experimental and therapeutic medicine

Wei Y,Zhang Z,Wang F,Zhou S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jan 01 00:00:00 UTC 2018

Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells.

Experimental and therapeutic medicine

Liu Y,Sun L,Chen W,Chuai J,Shang Y,Zhang D,Fu B,Tian H,Jiang S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Feb 01 00:00:00 UTC 2018

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.

Nature communications

Chen D,Xie J,Fiskesund R,Dong W,Liang X,Lv J,Jin X,Liu J,Mo S,Zhang T,Cheng F,Zhou Y,Zhang H,Tang K,Ma J,Liu Y,Huang B

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Feb 28 00:00:00 UTC 2018

Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.

Nature communications

Lopes N,Charaix J,Cédile O,Sergé A,Irla M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Mar 28 00:00:00 UTC 2018

Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3⁺RORγt⁺ Regulatory T Cells.

Cell reports

Ogawa C,Bankoti R,Nguyen T,Hassanzadeh-Kiabi N,Nadeau S,Porritt RA,Couse M,Fan X,Dhall D,Eberl G,Ohnmacht C,Martins GA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 02 00:00:00 UTC 2018

Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation.

International journal of molecular sciences

Soriano-Romaní L,Contreras-Ruiz L,López-García A,Diebold Y,Masli S

15-5773 was used in Flow cytometry/Cell sorting to identify the KRFK peptide as a novel therapeutic option to prevent the development of chronic inflammatory manifestations of the ocular surface.

Thu Dec 20 00:00:00 UTC 2018

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.

Nature communications

Hsieh WC,Hsu TS,Chang YJ,Lai MZ

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Jan 31 00:00:00 UTC 2018

Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.

Journal of neuroinflammation

Alizadeh A,Santhosh KT,Kataria H,Gounni AS,Karimi-Abdolrezaee S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Feb 21 00:00:00 UTC 2018

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice.

Scientific reports

Dar HY,Singh A,Shukla P,Anupam R,Mondal RK,Mishra PK,Srivastava RK

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Feb 06 00:00:00 UTC 2018

Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.

Scientific reports

Quan S,Principe DR,Dean AE,Park SH,Grippo PJ,Gius D,Horikoshi N

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Nov 07 00:00:00 UTC 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Nov 08 00:00:00 UTC 2018

REV-ERBα Regulates T_H17 Cell Development and Autoimmunity.

Cell reports

Amir M,Chaudhari S,Wang R,Campbell S,Mosure SA,Chopp LB,Lu Q,Shang J,Pelletier OB,He Y,Doebelin C,Cameron MD,Kojetin DJ,Kamenecka TM,Solt LA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Dec 26 00:00:00 UTC 2018

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.

Cancer cell

Palazon A,Tyrakis PA,Macias D,Veliça P,Rundqvist H,Fitzpatrick S,Vojnovic N,Phan AT,Loman N,Hedenfalk I,Hatschek T,Lövrot J,Foukakis T,Goldrath AW,Bergh J,Johnson RS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Nov 13 00:00:00 UTC 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Apr 12 00:00:00 UTC 2017

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.

The Journal of clinical investigation

Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Aug 01 00:00:00 UTC 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Mar 01 00:00:00 UTC 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Feb 01 00:00:00 UTC 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Nov 06 00:00:00 UTC 2017

IL-2 prevents deletion of developing T-regulatory cells in the thymus.

Cell death and differentiation

Hu DY,Wirasinha RC,Goodnow CC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Jun 01 00:00:00 UTC 2017

A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.

Gut microbes

Colpitts SL,Kasper EJ,Keever A,Liljenberg C,Kirby T,Magori K,Kasper LH,Ochoa-Repáraz J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Nov 02 00:00:00 UTC 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Aug 15 00:00:00 UTC 2017

Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Cooper ML,Choi J,Karpova D,Vij K,Ritchey J,Schroeder MA,DiPersio JF

15-5773 was used in Flow cytometry/Cell sorting to demonstrate that natural regulatory T cells are essential for azacitidine to fully protect against graft-versus-host disease and have important clinical implications for future clinical trials testing AzaC as a novel method of GvHD prophylaxis.

Mon May 01 00:00:00 UTC 2017

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.

The Journal of pharmacy and pharmacology

Makita N,Ishiguro J,Suzuki K,Nara F

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Jan 01 00:00:00 UTC 2017

SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.

Molecular pharmacology

Li J,Jing J,Bai Y,Li Z,Xing R,Tan B,Ma X,Qiu WW,Du C,Du B,Yang F,Tang J,Siwko S,Liu M,Chen H,Luo J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon May 01 00:00:00 UTC 2017

Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance.

Molecular medicine reports

Li Y,Li H,Cao Y,Wu F,Ma W,Wang Y,Sun S

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Dec 01 00:00:00 UTC 2017

Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice.

Molecular medicine reports

Tang A,Li C,Chen Z,Li T

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Oct 01 00:00:00 UTC 2017

B cells inhibit the antitumor immunity against an established murine fibrosarcoma.

Oncology letters

Maglioco A,Machuca DG,Badano MN,Nannini P,Camerano GV,Costa H,Meiss R,Ruggiero RA,Giordano M,Dran GI

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon May 01 00:00:00 UTC 2017

Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs.

Oncology letters

Son CH,Bae J,Lee HR,Yang K,Park YS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon May 01 00:00:00 UTC 2017

Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.

Oncology letters

Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Apr 01 00:00:00 UTC 2017

Proteomic changes of CD4⁺/CD25⁺/forkhead box p3⁺ regulatory T cells in a 30-day rat model of sepsis survival.

Experimental and therapeutic medicine

Jiao Y,Tan S,Xiong J

15-5773 was used in Flow cytometry/Cell sorting to explain the mechanism by which regulatory T-cells (Tregs) naturally recover and indicate that Tregs in the blood and spleen vary.

Fri Dec 01 00:00:00 UTC 2017

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP_SWE/PS1_ΔE9 murine model of Alzheimer's disease.

Scientific reports

Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Sep 05 00:00:00 UTC 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Apr 01 00:00:00 UTC 2017

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Scientific reports

Huang J,Wang L,Dahiya S,Beier UH,Han R,Samanta A,Bergman J,Sotomayor EM,Seto E,Kozikowski AP,Hancock WW

15-5773 was used in Flow cytometry/Cell sorting to examine the effects of global histone/protein deacetylase inhibition on regulatory T cell function.

Thu Aug 17 00:00:00 UTC 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Feb 06 00:00:00 UTC 2017

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.

Nature communications

Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Mar 27 00:00:00 UTC 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue May 09 00:00:00 UTC 2017

The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.

BMC complementary and alternative medicine

Xie L,Zhong X,Liu D,Liu L,Xia Z

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Dec 01 00:00:00 UTC 2017

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jan 12 00:00:00 UTC 2021

Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.

PloS one

Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Aug 17 00:00:00 UTC 2017

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

The Journal of biological chemistry

Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Feb 03 00:00:00 UTC 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Feb 13 00:00:00 UTC 2017

Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression.

PloS one

Medina-Colorado AA,Osorio EY,Saldarriaga OA,Travi BL,Kong F,Spratt H,Soong L,Melby PC

15-5773 was used in Flow cytometry/Cell sorting to show the expression of counter-regulatory molecules on splenic CD4+ T cells and macrophages promotes a permissive macrophage phenotype, attenuating intracellular parasite control.

Mon Aug 07 00:00:00 UTC 2017

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Cell

Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Aug 25 00:00:00 UTC 2016

B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.

European journal of immunology

Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Mar 01 00:00:00 UTC 2016

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.

Genes and immunity

Bearoff F,Del Rio R,Case LK,Dragon JA,Nguyen-Vu T,Lin CY,Blankenhorn EP,Teuscher C,Krementsov DN

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Dec 01 00:00:00 UTC 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Aug 01 00:00:00 UTC 2016

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

Molecular medicine reports

Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun May 01 00:00:00 UTC 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Aug 01 00:00:00 UTC 2016

Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Veterinary immunology and immunopathology

Wang Z,Navarro-Alvarez N,Shah JA,Zhang H,Huang Q,Zheng Q,Madsen JC,Sachs DH,Huang CA,Wang Z

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Dec 01 00:00:00 UTC 2016

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.

Nature communications

Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Apr 04 00:00:00 UTC 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Wed Jun 08 00:00:00 UTC 2016

Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.

JCI insight

Federico G,Meister M,Mathow D,Heine GH,Moldenhauer G,Popovic ZV,Nordström V,Kopp-Schneider A,Hielscher T,Nelson PJ,Schaefer F,Porubsky S,Fliser D,Arnold B,Gröne HJ

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Jan 21 00:00:00 UTC 2016

Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.

Clinical and molecular allergy : CMA

Petrarca C,Clemente E,Amato V,Gatta A,Cortese S,Lamolinara A,Rossi C,Zanotta S,Mistrello G,Paganelli R,Di Gioacchino M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Aug 08 00:00:00 UTC 2016

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

PloS one

Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Aug 25 00:00:00 UTC 2017

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

Nature communications

Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Aug 08 00:00:00 UTC 2016

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Scientific reports

Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jul 11 00:00:00 UTC 2016

Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

The Journal of clinical investigation

Millet A,Martin KR,Bonnefoy F,Saas P,Mocek J,Alkan M,Terrier B,Kerstein A,Tamassia N,Satyanarayanan SK,Ariel A,Ribeil JA,Guillevin L,Cassatella MA,Mueller A,Thieblemont N,Lamprecht P,Mouthon L,Perruche S,Witko-Sarsat V

15-5773 was used in Flow cytometry/Cell sorting to investigate disruption of immune silencing by proteinase 3 on apoptotic cells.

Mon Nov 02 00:00:00 UTC 2015

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

The Journal of clinical investigation

Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW

15-5773 was used in Flow cytometry/Cell sorting to show that histone/protein deacetylase 3 is essential for the normal development and suppressive functions of thymic and peripheral FOXP3+ Tregs.

Mon Mar 02 00:00:00 UTC 2015

Towards programming immune tolerance through geometric manipulation of phosphatidylserine.

Biomaterials

Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Dec 01 00:00:00 UTC 2015

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Dec 29 00:00:00 UTC 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sun Nov 01 00:00:00 UTC 2015

Leptin receptor signaling in T cells is required for Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jun 01 00:00:00 UTC 2015

Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis.

Allergy, asthma & immunology research

Son HL,Park HR,Park YJ,Kim SW

15-5773 was used in Flow cytometry/Cell sorting to investigate the effects of all-trans retinoic acid in an allergic rhinitis mouse model.

Sun Nov 01 00:00:00 UTC 2015

Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis.

Mediators of inflammation

Oliveira L,Correia A,Cristina Costa A,Guerra-Gomes S,Ferreirinha F,Magalhães-Cardoso MT,Vilanova M,Correia-de-Sá P

15-5773 was used in Flow cytometry/Cell sorting to investigate the role of ecto-5'-nucleotidase/CD73 in a rat model of experimental autoimmune myasthenia gravis.

Mon Jan 11 00:00:00 UTC 2016

Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes.

Clinical and vaccine immunology : CVI

Brown WC,Turse JE,Lawrence PK,Johnson WC,Scoles GA,Deringer JR,Sutten EL,Han S,Norimine J

15-5773 was used in Flow cytometry/Cell sorting to study the induction of T-cell exhaustion following infection with A. marginale and study the correlation with an increase in CD4(+) CD25(+) Foxp3(+) T cells.

Wed Jul 01 00:00:00 UTC 2015

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.

Nature communications

Baruch K,Rosenzweig N,Kertser A,Deczkowska A,Sharif AM,Spinrad A,Tsitsou-Kampeli A,Sarel A,Cahalon L,Schwartz M

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Aug 18 00:00:00 UTC 2015

Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer.

Oncotarget

Patel MR,Jacobson BA,Ji Y,Drees J,Tang S,Xiong K,Wang H,Prigge JE,Dash AS,Kratzke AK,Mesev E,Etchison R,Federspiel MJ,Russell SJ,Kratzke RA

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Oct 20 00:00:00 UTC 2015

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Scientific reports

Guo A,He D,Xu HB,Geng CA,Zhao J

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Sep 15 00:00:00 UTC 2015

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Sep 29 00:00:00 UTC 2015

MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.

Nature communications

Pratama A,Srivastava M,Williams NJ,Papa I,Lee SK,Dinh XT,Hutloff A,Jordan MA,Zhao JL,Casellas R,Athanasopoulos V,Vinuesa CG

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 06 00:00:00 UTC 2015

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.

Cancer cell

Xu C,Fillmore CM,Koyama S,Wu H,Zhao Y,Chen Z,Herter-Sprie GS,Akbay EA,Tchaicha JH,Altabef A,Reibel JB,Walton Z,Ji H,Watanabe H,Jänne PA,Castrillon DH,Rustgi AK,Bass AJ,Freeman GJ,Padera RF,Dranoff G,Hammerman PS,Kim CF,Wong KK

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon May 12 00:00:00 UTC 2014

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

Nature immunology

Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu May 01 00:00:00 UTC 2014

Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.

Circulation research

Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S

15-5773 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.

Fri Jun 20 00:00:00 UTC 2014

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.

Annals of neurology

Breuer J,Schwab N,Schneider-Hohendorf T,Marziniak M,Mohan H,Bhatia U,Gross CC,Clausen BE,Weishaupt C,Luger TA,Meuth SG,Loser K,Wiendl H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu May 01 00:00:00 UTC 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Jul 15 00:00:00 UTC 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Jan 05 00:00:00 UTC 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu May 01 00:00:00 UTC 2014

Direct detection of FoxP3 expression in thymic double-negative CD4-CD8- cells by flow cytometry.

Scientific reports

Liu G,Li Z,Wei Y,Lin Y,Yang C,Liu T

15-5773 was used in Flow cytometry/Cell sorting to suggest that Foxp3 expression in double-negative CD4+CD8+ T-cell precursors can directly be detected by flow cytometry.

Fri Jul 25 00:00:00 UTC 2014

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.

Nature immunology

Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 01 00:00:00 UTC 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Mar 01 00:00:00 UTC 2013

Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.

Diabetologia

Kuriya G,Uchida T,Akazawa S,Kobayashi M,Nakamura K,Satoh T,Horie I,Kawasaki E,Yamasaki H,Yu L,Iwakura Y,Sasaki H,Nagayama Y,Kawakami A,Abiru N

15-5773 was used in Flow cytometry/Cell sorting to study the suppression of diabetes in NOD mice due to IL-17 and IFN-γ deficiency.

Thu Aug 01 00:00:00 UTC 2013

Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production.

Acta pharmacologica Sinica

Kong FY,Chen W,He SJ,Lin ZM,Li X,Zhang XH,Yang XQ,Zhu FH,Tong XK,Zhou Y,Tang W,Duan WH,Zuo JP

15-5773 was used in Flow cytometry/Cell sorting to investigate the interaction between the mycophenolic acid derivative, 118, and the immune environment in a murine allogeneic skin graft model.

Mon Jul 01 00:00:00 UTC 2013

PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.

Tissue engineering. Part A

Graham JG,Zhang X,Goodman A,Pothoven K,Houlihan J,Wang S,Gower RM,Luo X,Shea LD

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Sat Jun 01 00:00:00 UTC 2013

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Thu Jul 31 00:00:00 UTC 2014

Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.

PloS one

Jia W,Cao L,Yang S,Dong H,Zhang Y,Wei H,Jing W,Hou L,Wang C

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Dec 17 00:00:00 UTC 2013

Artemisinin analogue SM934 ameliorates murine experimental autoimmune encephalomyelitis through enhancing the expansion and functions of regulatory T cell.

PloS one

Li X,Li TT,Zhang XH,Hou LF,Yang XQ,Zhu FH,Tang W,Zuo JP

15-5773 was used in Flow cytometry/Cell sorting to explore the effects of SM934 on Th1, Th17 and Treg cell differentiation.

Wed Apr 16 00:00:00 UTC 2014

Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice.

Circulation

Hofmann U,Beyersdorf N,Weirather J,Podolskaya A,Bauersachs J,Ertl G,Kerkau T,Frantz S

15-5773 was used in Flow cytometry/Cell sorting to investigate the role of CD4+ T lymphocytes in wound healing after experimental myocardial infarction in mice.

Tue Apr 03 00:00:00 UTC 2012

Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Mineharu Y,Muhammad AK,Yagiz K,Candolfi M,Kroeger KM,Xiong W,Puntel M,Liu C,Levy E,Lugo C,Kocharian A,Allison JP,Curran MA,Lowenstein PR,Castro MG

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Mon Oct 01 00:00:00 UTC 2012

Role of donor-specific regulatory T cells in long-term acceptance of rat hind limb allograft.

PloS one

Wang Y,Zheng Z,Wang Y,Liu J,Li N,Hu X,Han F,Liu Y,Hu D

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Feb 19 00:00:00 UTC 2013

Pharyngeal microflora disruption by antibiotics promotes airway hyperresponsiveness after respiratory syncytial virus infection.

PloS one

Ni K,Li S,Xia Q,Zang N,Deng Y,Xie X,Luo Z,Luo Y,Wang L,Fu Z,Liu E

15-5773 was used in Flow cytometry/Cell sorting to demonstrate that antibiotic treatment clears pharyngeal commensal bacteria and depletes levels of pulmonary Tregs.

Wed Nov 28 00:00:00 UTC 2012

CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.

Journal of neuroinflammation

Göbel K,Bittner S,Melzer N,Pankratz S,Dreykluft A,Schuhmann MK,Meuth SG,Wiendl H

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Feb 28 00:00:00 UTC 2012

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.

The American journal of pathology

Yamamoto Y,Otani S,Hirai H,Nagata K,Aritake K,Urade Y,Narumiya S,Yokozeki H,Nakamura M,Satoh T

15-5773 was used in Flow cytometry/Cell sorting to demonstrate that prostaglandin D2 signals through CRTH2 and DP to mediate contact hypersensitivity.

Fri Jul 01 00:00:00 UTC 2011

MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

Journal of immunology (Baltimore, Md. : 1950)

McPhee CG,Sproule TJ,Shin DM,Bubier JA,Schott WH,Steinbuck MP,Avenesyan L,Morse HC,Roopenian DC

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Tue Nov 01 00:00:00 UTC 2011

Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.

Journal of immunology (Baltimore, Md. : 1950)

Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G

15-5773 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.

Tue Feb 01 00:00:00 UTC 2011

CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.

Journal of immunology (Baltimore, Md. : 1950)

Erhardt A,Wegscheid C,Claass B,Carambia A,Herkel J,Mittrücker HW,Panzer U,Tiegs G

15-5773 was used in Flow cytometry/Cell sorting to discovered that CXCR3(+)T-bet(+)IL-10(+) Tregs are generated in the liver, disseminate into the organism and migrate into the liver, limiting immune-mediated liver damage.

Sun May 01 00:00:00 UTC 2011

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.

Blood

Choi J,Ritchey J,Prior JL,Holt M,Shannon WD,Deych E,Piwnica-Worms DR,DiPersio JF

15-5773 was used in Flow cytometry/Cell sorting to demonstrate that hypomethylating agents, decitabine and azacitidine, induce FOXP3 expression in CD4(+)CD25(-) T cells both in vitro and in vivo.

Thu Jul 08 00:00:00 UTC 2010

CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Kitamura K,Farber JM,Kelsall BL

15-5773 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.

Wed Sep 15 00:00:00 UTC 2010

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.

Self/nonself

Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM

Published figure using FOXP3 monoclonal antibody (Product # 15-5773-82) in Flow Cytometry

Fri Oct 01 00:00:00 UTC 2010

Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen.

Journal of autoimmunity

Morris GP,Brown NK,Kong YC

15-5773 was used in Flow cytometry/Cell sorting to highlight the important role of Tregs in mediating self-tolerance in relation to experimental autoimmune thyroiditis.

Sat Aug 01 00:00:00 UTC 2009

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.

The Journal of experimental medicine

Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G

15-5773 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.

Mon Jun 09 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: Forkhead box protein P3; forkhead/winged helix transcription factor 3; Foxp3; MGC141961; MGC141963; RP23-54C14.1; Scurfin; scurfy

Gene Aliases: Foxp3; JM2; RGD1562112; scurfin; sf

UniProt ID: (Mouse) Q99JB6

Entrez Gene ID: (Dog) 491876, (Pig) 444998, (Bovine) 506053, (Cat) 100037405, (Mouse) 20371, (Rat) 317382

Function(s)

core promoter binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription corepressor activity protein binding histone acetyltransferase binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding metal ion binding NFAT protein binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function

Process(es)

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FOXP3 Monoclonal Antibody (FJK-16s), PE-Cyanine5, eBioscience™

FOXP3 Antibody (15-5773-82) in Flow

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15-5773-82

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FOXP3 Monoclonal Antibody (FJK-16s), PE-Cyanine5, eBioscience™

FOXP3 Antibody (15-5773-82) in Flow

Product Details

15-5773-82

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

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