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Product Details
PA5-53114
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FUT11. Recombinant protein control fragment (Product #RP-90784).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641787
Product Specific Information
Immunogen sequence: MKYLAYKQPG GITNQFLLDS LKHREWGVND PLLPNYLNGF ECFVCDYELA RLDAEKAHAA SPGDSPVFEP HIAQPSHMDC PVPTPGFGNV EEIPENDSWK EMWLQDYWQG LDQGEALTAM IHNNETEQTK FWDYL
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 89%.
Target Information
The FUT11 gene encodes for fructosyltransferase 11, an enzyme that is part of the glycosyltransferase family involved in the modification of glycoproteins and glycolipids by catalyzing the addition of fucose moieties. Enzymes like FUT11 play a critical role in the biosynthesis of Lewis antigen structures, significantly contributing to cell-cell adhesion, signal transduction, and immune recognition. Fucosylation, the process mediated by fructosyltransferases, is crucial for various biological functions, including the regulation of leukocyte trafficking and selectin binding, emphasizing its importance in immune responses and inflammation. While FUT11 is less characterized compared to other fucosyltransferases, altered expression patterns and functional abnormalities in these enzymes are linked to pathological conditions, such as cancer and inflammatory diseases, where changes in glycosylation can affect tumor progression, metastasis, and immune evasion. Ongoing research into FUT11 aims to elucidate its specific role in cellular processes and explore potential therapeutic applications by targeting fucosylation pathways to modify disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha (1,3) fucosyltransferase; Alpha-(1,3)-fucosyltransferase 11; EC 2.4.1; Fuc-TXI; Fucosyltransferase 11; fucosyltransferase 11 (alpha (1,3) fucosyltransferase); Fucosyltransferase XI; fucT-XI; Galactoside 3-L-fucosyltransferase 11; MGC119338; MGC119339; MGC33202
Gene Aliases: FUT11
UniProt ID: (Human) Q495W5
Entrez Gene ID: (Human) 170384
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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