Loading ...

Invitrogen

FZD4 Monoclonal Antibody (2F3A7)

View all (14) FZD4 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Product Details

MA5-48644

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Flow Cytometry (Flow)

1:200-1:400

ELISA (ELISA)

1:10,000

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2F3A7

Immunogen

Purified recombinant fragment of human CD344 (AA: extra 37-222) expressed in E. Coli.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_3090869

Target Information

FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: CD344; CD344 antigen; frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4; Frizzled-4; Fz-4; FzE4; MGC34390; WNT receptor frizzled-4

Gene Aliases: CD344; EVR1; FEVR; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4

UniProt ID: (Human) Q9ULV1

Entrez Gene ID: (Human) 8322

Function(s)

G-protein coupled receptor activity protein binding Wnt-protein binding cytokine binding PDZ domain binding ubiquitin protein ligase binding protein homodimerization activity Wnt-activated receptor activity protein heterodimerization activity transmembrane signal receptor

Process(es)

vasculogenesis G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway sensory perception of sound negative regulation of cell-substrate adhesion Wnt signaling pathway neuron differentiation regulation of vascular endothelial growth factor receptor signaling pathway locomotion involved in locomotory behavior substrate adhesion-dependent cell spreading extracellular matrix-cell signaling progesterone secretion positive regulation of JUN kinase activity positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway retina vasculature morphogenesis in camera-type eye cerebellum vasculature morphogenesis retinal blood vessel morphogenesis cellular response to retinoic acid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more