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Myosin is a 480 kD protein that interacts with actin in muscle and non muscle cells (8). Conventional myosin contains two identical heavy chains (MHC - 200kD each) and four light chains (MLC-15-26 kD). Conventional myosin molecules consist of two major regions: tail (rod) and globular heads; they aggregate into filaments through the tail region and interact with actin and with adenosine triphosphate (ATP) through the head region. Multiple forms of myosin heavy chains exist in skeletal, smooth and cardiac muscle and in non- muscle tissues. A spectrum of skeletal muscle fiber types is found in adult skeletal muscles. The two major skeletal muscle fiber types are type I (slow- twitch) and type II (fast-twitch). Skeletal muscle type II fibers can be further subdivided into types IIa (fast red) and IIb (fast white).
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Protein Aliases: MLC-2; MLC-2A; MLC20; MLC2a; myLC-2; MYLC2; Myosin light chain 2, lymphocyte-specific; myosin light chain 2, precursor lymphocyte-specific; myosin light chain 2a; Myosin light chain 5; myosin light chain, regulatory A; myosin light chain, regulatory B; Myosin regulatory light chain 10; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2, atrial isoform; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain 5; Myosin regulatory light chain 7; Myosin regulatory light chain MRLC2; myosin regulatory light chain-B; Myosin RLC-B; myosin, light chain 10, regulatory; myosin, light chain 10, regulatory, pseudogene 1; myosin, light chain 12B, regulatory; myosin, light chain 5, regulatory; myosin, light chain 7, regulatory; myosin, light polypeptide 5, regulatory; myosin, light polypeptide 7, regulatory; Precursor lymphocyte-specific regulatory light chain; SHUJUN-1; Superfast myosin regulatory light chain 2
Gene Aliases: 1500001M02Rik; 1700027I08Rik; C77744; MLC-2alpha; MLC-B; MLC2a; MRLC2; Mrlcb; MYL10; Myl10-ps1; MYL12B; MYL2A; MYL5; MYL7; MYLC2A; MYLC2B; MYLC2PL; PLRLC; RGD1561258; RLC-A; RLC-B
UniProt ID: (Human) Q9BUA6, (Human) O14950, (Human) Q02045, (Human) Q01449, (Mouse) Q62082, (Rat) P18666, (Mouse) Q3THE2, (Mouse) Q9QVP4
Entrez Gene ID: (Human) 93408, (Human) 103910, (Human) 4636, (Human) 58498, (Rat) 501831, (Mouse) 59310, (Rat) 50685, (Mouse) 67938, (Rat) 289759, (Mouse) 17898
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