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Invitrogen

Folate Receptor alpha Polyclonal Antibody

2 Published Figures

6 References

View all (31) Folate Receptor alpha antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (5)
Published Figures (2)

Application

Folate Receptor alpha Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

Folate Receptor alpha Antibody (PA5-42004) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human adult liver tissue using an anti-FOLR1 polyclonal antibody (Product # PA5-42004).

Folate Receptor alpha Antibody in Western Blot (WB)

Folate Receptor alpha Antibody in Immunocytochemistry (ICC/IF)

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Product Details

PA5-42004

Applications

Tested Dilution

Publications

Western Blot (WB)

0.2-1 µg/mL

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:600

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the middle region of human FOLR1

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2609391

Product Specific Information

Peptide sequence: HFYFPTPTVL CNEIWTHSYK VSNYSRGSGR CIQMWFDPAQ GNPNEEVARF

Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats.

Frontiers in pharmacology

Li HZ,Liu KG,Zeng NX,Wu XF,Lu WJ,Xu HF,Yan C,Wu LL

PA5-42004 was used in Immunohistochemistry (Paraffin), Western Blot to suggest that luteolin could ameliorate CUMS-induced LOD-like behaviors by enhancing the folate brain transport.

Wed Apr 13 00:00:00 UTC 2022

Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice.

Diabetologia

Fukaishi T,Nakagawa Y,Fukunaka A,Sato T,Hara A,Nakao K,Saito M,Kohno K,Miyatsuka T,Tamaki M,Matsuhisa M,Matsuoka TA,Yamada T,Watada H,Fujitani Y

PA5-42004 was used in Immunohistochemistry to investigate the association between Ppy-lineage cells and beta cells, using Ppy-Cre driver mice and a PP-specific monoclonal antibody.

Wed Dec 01 00:00:00 UTC 2021

Identification of a PET Radiotracer for Imaging of the Folate Receptor-α: A Potential Tool to Select Patients for Targeted Tumor Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Guzik P,Fang HY,Deberle LM,Benešová M,Cohrs S,Boss SD,Ametamey SM,Schibli R,Müller C

PA5-42004 was used in Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry to identify a folate receptor-α (FRα)-selective PET agent potentially suitable for the selection of patients who might profit from FRα-targeted therapies.

Fri Oct 01 00:00:00 UTC 2021

Identification of a PET Radiotracer for Imaging of the Folate Receptor-α: A Potential Tool to Select Patients for Targeted Tumor Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Guzik P,Fang HY,Deberle LM,Benešová M,Cohrs S,Boss SD,Ametamey SM,Schibli R,Müller C

Fri Oct 01 00:00:00 UTC 2021

Identification of a PET Radiotracer for Imaging of the Folate Receptor-α: A Potential Tool to Select Patients for Targeted Tumor Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Guzik P,Fang HY,Deberle LM,Benešová M,Cohrs S,Boss SD,Ametamey SM,Schibli R,Müller C

Fri Oct 01 00:00:00 UTC 2021

Identification of a PET Radiotracer for Imaging of the Folate Receptor-α: A Potential Tool to Select Patients for Targeted Tumor Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Guzik P,Fang HY,Deberle LM,Benešová M,Cohrs S,Boss SD,Ametamey SM,Schibli R,Müller C

Fri Oct 01 00:00:00 UTC 2021

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.

PLoS pathogens

Simanjuntak Y,Ko HY,Lee YL,Yu GY,Lin YL

Published figure using Folate Receptor alpha polyclonal antibody (Product # PA5-42004) in Immunocytochemistry

Fri May 01 00:00:00 UTC 2020

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.

PLoS pathogens

Simanjuntak Y,Ko HY,Lee YL,Yu GY,Lin YL

Published figure using Folate Receptor alpha polyclonal antibody (Product # PA5-42004) in Immunocytochemistry

Fri May 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Adult folate-binding protein; FBP; folate binding protein; Folate receptor 1; folate receptor 1 (adult); Folate receptor alpha; Folate receptor, adult; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18

Gene Aliases: FBP; FOLR; FOLR1

UniProt ID: (Human) P15328

Entrez Gene ID: (Human) 2348

Function(s)

receptor activity folic acid binding drug binding folic acid transporter activity methotrexate binding folic acid receptor activity

Process(es)

heart looping neural crest cell migration involved in heart formation cardiac neural crest cell migration involved in outflow tract morphogenesis ER to Golgi vesicle-mediated transport receptor-mediated endocytosis folic acid transport regulation of transforming growth factor beta receptor signaling pathway axon regeneration folic acid metabolic process COPII vesicle coating regulation of canonical Wnt signaling pathway pharyngeal arch artery morphogenesis anterior neural tube closure cellular response to folic acid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Folate Receptor alpha Polyclonal Antibody

Folate Receptor alpha Antibody (PA5-42004) in IHC (P)

Product Details

PA5-42004

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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