Invitrogen

Folliculin Polyclonal Antibody

View all (12) Folliculin antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-100247

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FLCN(Accession Q8NFG4), corresponding to amino acid residues S56-Y106.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2815777

Product Specific Information

Antibody detects endogenous levels of total FLCN.

Target Information

This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Birt-Hogg-Dube syndrome protein homolog; Folliculin

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Gene Aliases: AU014660; B430214A04Rik; BHD; FLCL; FLCN

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UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3, (Rat) Q76JQ2

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Entrez Gene ID: (Human) 201163, (Mouse) 216805, (Rat) 303185

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Function(s)
guanyl-nucleotide exchange factor activity protein binding protein complex binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation cell-cell junction assembly positive regulation of autophagy negative regulation of gene expression negative regulation of mitochondrion organization hemopoiesis negative regulation of cell growth negative regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway TOR signaling regulation of TOR signaling negative regulation of TOR signaling positive regulation of TOR signaling regulation of cytokinesis negative regulation of Rho protein signal transduction regulation of histone acetylation positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of protein localization to nucleus negative regulation of cell proliferation involved in kidney development negative regulation of energy homeostasis regulation of pro-B cell differentiation negative regulation of ATP biosynthetic process negative regulation of angiogenesis negative regulation of transcription, DNA-templated negative regulation of cellular respiration negative regulation of mitochondrial DNA metabolic process negative regulation of muscle tissue development negative regulation of post-translational protein modification positive regulation of intrinsic apoptotic signaling pathway biological_process
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