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Proteintech

Follistatin Monoclonal Antibody (4E9B10)

View all (25) Follistatin antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (7)

Application

Follistatin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

Follistatin Antibody (60060-1-IG) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HeLa cells using 60060-1-IG (Follistatin antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

Follistatin Antibody in Immunocytochemistry (ICC/IF)

Follistatin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Follistatin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Follistatin Antibody in Western Blot (WB)

Follistatin Antibody in Western Blot (WB)

Follistatin Antibody in Western Blot (WB)

Follistatin Antibody in Western Blot (WB)

Product Image Gallery

Follistatin Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol) fixed HeLa cells using 60060-1-IG (Follistatin antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

Follistatin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using 60060-1-IG ( Follistatin antibody at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Follistatin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using 60060-1-IG ( Follistatin antibody at dilution of 1:400 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Follistatin Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with (Product # 60060-1-Ig) Follistatin antibody at dilution of 1:3,000 incubated at room temperature for 1.5 hours.

Follistatin Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 60060-1-IG (Follistatin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Follistatin Antibody in Western Blot (WB) — Raji cells were subjected to SDS PAGE followed by western blot with 60060-1-Ig (Follistatin antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Follistatin Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 60060-1-Ig (Follistatin antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

60060-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

-

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

-

Immunocytochemistry (ICC/IF)

1:50-1:500

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

4E9B10

Immunogen

Follistatin Fusion Protein Ag0775 (1-344 aa encoded by BC004107)

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVRARHQPG GLCLLLLLLC QFMEDRSAQA GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCNSI SEDTEEEEED EDQDYSFPIS SILEW (1-344 aa encoded by BC004107)

Target Information

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.

Cells

Nagayama I,Takayanagi K,Hasegawa H,Maeshima A

Sat Mar 04 00:00:00 UTC 2023

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Tong J,Cong L,Jia Y,He BL,Guo Y,He J,Li D,Zou B,Li J

Fri Nov 04 00:00:00 UTC 2022

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.

PeerJ

Yanazawa K,Sugasawa T,Aoki K,Nakano T,Kawakami Y,Takekoshi K

Wed Apr 27 00:00:00 UTC 2022

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.

PeerJ

Yanazawa K,Sugasawa T,Aoki K,Nakano T,Kawakami Y,Takekoshi K

Wed Apr 27 00:00:00 UTC 2022

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.

PeerJ

Yanazawa K,Sugasawa T,Aoki K,Nakano T,Kawakami Y,Takekoshi K

Wed Apr 27 00:00:00 UTC 2022

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.

PeerJ

Yanazawa K,Sugasawa T,Aoki K,Nakano T,Kawakami Y,Takekoshi K

Wed Apr 27 00:00:00 UTC 2022

Screening and Identification of Differential Ovarian Proteins before and after Induced Ovulation via Seminal Plasma in Bactrian Camels.

Animals : an open access journal from MDPI

Wang Q,Zhang Q,Li Y,Zhao X,Zhang Y

Thu Dec 09 00:00:00 UTC 2021

Screening and Identification of Differential Ovarian Proteins before and after Induced Ovulation via Seminal Plasma in Bactrian Camels.

Animals : an open access journal from MDPI

Wang Q,Zhang Q,Li Y,Zhao X,Zhang Y

Thu Dec 09 00:00:00 UTC 2021

Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β-Smad3 Pathway.

Frontiers in pharmacology

Wang Y,Yu K,Zhao C,Zhou L,Cheng J,Wang DW,Zhao C

Sat Aug 14 00:00:00 UTC 2021

Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease.

Antioxidants & redox signaling

Mehta N,Gava AL,Zhang D,Gao B,Krepinsky JC

Tue Sep 10 00:00:00 UTC 2019

Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.

Fertility and sterility

Carrarelli P,Yen CF,Arcuri F,Funghi L,Tosti C,Wang TH,Huang JS,Petraglia F

Tue Sep 01 00:00:00 UTC 2015

Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.

Fertility and sterility

Carrarelli P,Yen CF,Arcuri F,Funghi L,Tosti C,Wang TH,Huang JS,Petraglia F

Tue Sep 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Activin-binding protein; Follictatin; Follistatin; follistatin isoform FST317; FS

Gene Aliases: AL033346; FS; FST

UniProt ID: (Human) P19883, (Mouse) P47931

Entrez Gene ID: (Human) 10468, (Mouse) 14313

Function(s)

signal transducer activity protein binding heparan sulfate proteoglycan binding activin binding protease inhibitor

Process(es)

negative regulation of transcription from RNA polymerase II promoter hematopoietic progenitor cell differentiation signal transduction negative regulation of activin receptor signaling pathway positive regulation of hair follicle development skeletal system development gamete generation pattern specification process female gonad development BMP signaling pathway hair follicle morphogenesis odontogenesis of dentin-containing tooth keratinocyte proliferation negative regulation of cell differentiation

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