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GABA(A) alpha 5 Receptor Antibody (AGA-025-200UL) in IHC
Expression of GABRA5 in mouse brain - Immunohistochemical staining of mouse hippocampus sections using Anti-GABA (A) alpha 5 Receptor Antibody (#AGA-025), (1;600). A. GABRA5 staining (green).B. Merged image of GABRA5 (green) with nuclei staining using DAPI as the counterstain (blue). GABRA5 is detected in the pyramidal layer (Pyr) (horizontal arrows) and in some interneurons (vertical arrow).
Product Details
AGA-025-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KKERELILNKSTN, corresponding to amino acid residues 364-376 of rat GABRA5, 2ndintracellular loop
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
Gene Aliases: A230018I05Rik; Gabra-5; Gabra5
UniProt ID: (Rat) P19969, (Mouse) Q8BHJ7
Entrez Gene ID: (Rat) 29707, (Mouse) 110886
behavioral fear response
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
brain development
sensory perception of sound
associative learning
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
neuron development
inner ear receptor cell development
innervation
cochlea development
chloride transmembrane transport
positive regulation of defense response to virus by host
transport
ion transport
chloride transport
signal transduction
mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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