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Product Details
H00026130-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GAPVD1 (AAH21119.1, 1 a.a. approximately 629 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MQEDESYLLQ VLRYLIEFEL KESDNPRRLL RRGTCAFSIL FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ EKLFGEKGSD RFRQKVQEMV ESNEAKLVAL VNKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVDRLEVGE VRAMCTDLLL ACFICPAVVN PEQYGIISDA PINEVARFNL MQVGRLLQQL AMTGSEEGDP RTKSSLGKFD KSCVAAFLDV VIGGRAVETP PLSSVNLLEG LSRTVVYITY SQLITLVNFM KSVMSGDQLR EDRMALDNLL ANLPPAKPGK SSSLEMTPYN TPQLSPATTP ANKKNRLPIA TRSRSRTNML MDLHMDHEGS SQETIQEVQP EEVLVISLGT GPQLTPGMIS ENEVLNMQLS DGGQGDVPVD ENKLHGKPDK TLRFSLCSDN LEGISEGPSN RSNSVSSLDL EGESVSELGA GPSGSNGVEA LQLLEHEQAT TQDNLDDKLR KFEIRDMMGL TDDRDISETV SETWSTDVLG SDFDPNIDED RLQEIAGAAA ENMLGSLLCL PGSGSVLLDP CTGSTISETT SEAWSVEVLP SDSEAPDLKQ EERLQELESF LDWVAHLMIR MSGRSVPAPA HQASVLCPA
Target Information
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP434C212; GAPex-5; GTPase-activating protein and VPS9 domain-containing protein 1; MGC138847; MGC138848; Rab5-activating protein 6
Gene Aliases: GAPex-5; GAPEX5; GAPVD1; KIAA1521; RAP6
UniProt ID: (Human) Q14C86
Entrez Gene ID: (Human) 26130
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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