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Product Details
PA5-51688
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GART. Recombinant protein control fragment (Product #RP-101894).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2641871
Product Specific Information
Immunogen sequence: IEFVVVGPEA PLAAGIVGNL RSAGVQCFGP TAEAAQLESS KRFAKEFMDR HGIPTAQWKA FTKPEEACSF ILSADFPALV VKASGLAAGK GVIVAKSKEE ACKAVQEIMQ EKAFGAAGET IVIEELLDGE EVSCLCFTDG KTV
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.
Target Information
MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycinamide ribonucleotide formyltransferase; MGC47764; Trifunctional purine biosynthetic protein adenosine-3
Gene Aliases: AIRS; Gaps; GARS; GART; GARTF; PAIS; PGFT; PRGS
UniProt ID: (Human) P22102, (Mouse) Q64737
Entrez Gene ID: (Human) 2618, (Mouse) 14450, (Rat) 288259
phosphoribosylamine-glycine ligase activity
phosphoribosylformylglycinamidine cyclo-ligase activity
phosphoribosylglycinamide formyltransferase activity
ATP binding
metal ion binding
nucleotide binding
catalytic activity
methyltransferase activity
transferase activity
hydroxymethyl-, formyl- and related transferase activity
ligase activity
transferase
metabolite interconversion enzyme
ligase
brainstem development
'de novo' IMP biosynthetic process
glycine metabolic process
purine nucleobase biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
response to organic substance
response to inorganic substance
cerebellum development
cerebral cortex development
tetrahydrofolate biosynthetic process
purine nucleotide biosynthetic process
metabolic process
biosynthetic process
ribonucleoside monophosphate biosynthetic process
cobalamin metabolic process
methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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