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Bioss
GCAP2 Polyclonal Antibody
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Product Details
BS-13307R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GCAP2, amino acids 21-120.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Guanylate cyclase-activating proteins (GCAPs) are calcium binding proteins that belong to the calmodulin superfamily. GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation. Studies have shown that the addition or subtraction of Ca2+ results in major conformational changes and the activation/deactivation of GCAP-1 and GCAP-2. It has been demonstrated that both GCAP-1 and 2 act on guanylate cyclase similarly and have approximately 50% homology between the two forms. GCAP-1 is predominantly localized in the photoreceptor outer segments, while GCAP-2 is found in retina samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686E1183; GCAP 2; GCAP2 (retina); Guanylate cyclase activator 1B; guanylate cyclase activator 1B (retina); guanylate cyclase-activating protein, photoreceptor 2; Guanylin 2; Guanylyl cyclase-activating protein 2; GUCA 2
Gene Aliases: BC018258; GCAP2; GUCA1B; GUCA2; RP48
UniProt ID: (Human) Q9UMX6, (Mouse) Q8VBV8
Entrez Gene ID: (Human) 2979, (Mouse) 107477, (Rat) 316218
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