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This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Chorion-specific transcription factor GCMb; GCM motif protein 2; glial cells missing 2; Glial cells missing homolog 2; glial cells missing homolog b; glide/gcm protein homolog; hGCMb; mGCMb; RP3-417M14.3
Gene Aliases: Gcm-rs1; Gcm1; Gcm1-rs2; GCM2; GCMB; hGCMb
UniProt ID: (Human) O75603, (Mouse) O09102
Entrez Gene ID: (Human) 9247, (Rat) 291047, (Mouse) 107889
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