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Application
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GCNF Antibody (PA5-65400) in ICC/IF
Immunofluorescent staining of GCNF in human cell line CACO-2 shows localization to nucleoplasm. Samples were probed using a GCNF Polyclonal Antibody (Product # PA5-65400).
Product Details
PA5-65400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human GCNF. Recombinant protein control fragment (Product #RP-104805).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2663342
Product Specific Information
Immunogen sequence: QEFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSSR SVELNGFMAF REQYMGMSVP PHYQYIPHLF SYSGHSPLLP QQARSLDPQS YSLIHQLLSA EDLEPLGTPM LIEDGYA
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 96%.
Target Information
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GCNF; Germ cell nuclear factor; germ cell nuclear factor variant 1; h hRTR; Nuclear receptor subfamily 6 group A member 1; nuclear receptor subfamily 6, group A, member 1; retinoic acid receptor-related testis-associated receptor; Retinoid receptor-related testis-specific receptor; RTR
Gene Aliases: CT150; GCNF; GCNF1; hGCNF; hRTR; NR61; NR6A1; RTR
UniProt ID: (Human) Q8NHQ0
Entrez Gene ID: (Human) 2649
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
zinc ion binding
protein homodimerization activity
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
gamete generation
spermatogenesis
cell proliferation
intracellular steroid hormone receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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