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Invitrogen
GDNF Polyclonal Antibody
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Application
FIGURE: 1 / 4
GDNF Antibody (PA5-89957) in ICC/IF
Immunofluorescence analysis of GDNF in SH-SY5Y cells. Samples were incubated with GDNF Polyclonal antibody (Product # PA5-89957) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Product Details
PA5-89957
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 109-211 of human GDNF (NP_0005051)
Conjugate
Unconjugated
Form
Liquid
Concentration
2.02 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805864
Product Specific Information
Immunogen sequence: RGQRGKNRGC VLTAIHLNVT DLGLGYETKE ELIFRYCSGS CDAAETTYDK ILKNLSRNRR LVSDKVGQAC CRPIAFDDDL SFLDDNLVYH ILRKHSAKRC GCI; Positive Samples: Mouse brain, Mouse kidney, Rat brain
Target Information
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor
Gene Aliases: AI385739; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3
UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731
Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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