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GIMAP8 Antibody (PA5-53175) in IHC
Immunohistochemical staining of GIMAP8 in human lymph node using a GIMAP8 Polyclonal Antibody (Product # PA5-53175) shows cytoplasmic positivity in germinal center cells and non-germinal center cells.
Product Details
PA5-53175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GIMAP8. Recombinant protein control fragment (Product #RP-90833).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642002
Product Specific Information
Immunogen sequence: PDISSLKNID SEVRKHICTG PHAFLLVTPL GFYTKNDEAV LSTIQNNFGE KFFEYMIILL TRKEDLGDQD LDTFLRNSNK ALYGLIQKCK NRYSAFNYRA TGEEEQRQAD ELLEKIESMV HQNGNK
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 56%.
Target Information
The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN-9; Immune-associated nucleotide-binding protein 9; Protein IanT
Gene Aliases: GIMAP8; IAN-9; IAN6; IAN9; IANT
UniProt ID: (Human) Q8ND71
Entrez Gene ID: (Human) 155038
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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