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Invitrogen
GNAO1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-59337
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GNAO1. Recombinant protein control fragment (Product #RP-102901).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642080
Product Specific Information
Immunogen sequence: IQSLAAIVRA MDTLGIEYGD KERKADAKMV CDVVSRMEDT EPFSAELLSA MMRLWGDSGI QECF
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.
Target Information
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686O0962; G alpha o; GNAO 1; GO2-q chimeric G-protein; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2
Gene Aliases: EIEE17; G-ALPHA-o; GNAO; GNAO1; HLA-DQB1
UniProt ID: (Human) P09471
Entrez Gene ID: (Human) 2775
GTPase activity
signal transducer activity
GTP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
GTPase activating protein binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
heterotrimeric G-protein
protein folding
muscle contraction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
dopamine receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
aging
locomotory behavior
regulation of heart contraction
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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