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Glucosamine-6 phosphate-N-acetyl Transferase (GNPNAT1) is a key enzyme in the hexosamine biosynthetic pathway. It converts D-glucosamine 6-phosphate to N-acetyl-D-glucosamine 6-phosphate, the acetylation step allowing carbon and nitrogen enter into the hexosamine biosynthetic pathway. Recently inhibition of GNPNAT1 has been reported to promote proliferation and aggressiveness of castration-resistant prostate cancer. (27194471).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glucosamine 6-phosphate N-acetyltransferase; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase 1; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase; Phosphoglucosamine acetylase; Phosphoglucosamine transacetylase; Protein EMeg32
Gene Aliases: AU017428; AU040593; EMeg32; GNA1; GNPNAT; GNPNAT1; Gpnat1; Gsnpat
UniProt ID: (Human) Q96EK6, (Mouse) Q9JK38
Entrez Gene ID: (Human) 64841, (Mouse) 54342
Molecular Function:
acetyltransferase
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