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Product Details
12454-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GPAM fusion protein Ag3120
Conjugate
Unconjugated
Form
Liquid
Concentration
0.75 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SCAIMSTHIV ACLLLYRHRQ GIDLSTLVED FFVMKEEVLA RDFDLGFSGN SEDVVMHAIQ LLGNCVTITH TSRNDEFFIT PSTTVPSVFE LNFYSNGVLH VFIMEAIIAC SLYAVLNKRG LGGPTSTPPN LISQEQLVRK AASLCYLLSN EGTISLPCQT FYQVCHETVG KFIQYGILTV AEHDDQEDIS PSLAEQQWDK KLPEPLSWRS DEEDEDSDFG EEQRDCYLKV SQSKEHQQFI TFLQRLLGPL LEAYSSAAIF VHNFSGPVPE PEYLQKLHKY LITRTERNVA VYAESATYCL VKNAVKMFKD IGVFKETKQK RVSVLELSST FLPQCNRQKL LEYILSFVVL
Target Information
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; P90; RP11-426E5.2
Gene Aliases: Gpam; GPAT; GPAT1
UniProt ID: (Mouse) Q61586
Entrez Gene ID: (Mouse) 14732
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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