Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rabbit (100%) Orangutan, Mouse, Rat, Dog, Hamster, Elephant, Panda, Horse (92%).
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
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Protein Aliases: glycogen phosphorylase B; Glycogen phosphorylase, brain form; MGC9213; phosphorylase, glycogen; brain
Gene Aliases: GPBB; PYGB
UniProt ID: (Human) P11216
Entrez Gene ID: (Human) 5834, (Rabbit) 100342407
Molecular Function:
glycosyltransferase
transferase
metabolite interconversion enzyme
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