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Immunogen sequence: PLSLHEHEP AGEEALRQKR AVATKSPTAE EYTVNIEISF ENASFLDPIK AYLNSLSFPI HGNNTDQITD ILSINVTTVC RPAGNEIWCS CETGYGWPRE RCLHNLICQE RDVFLPGHHC SCLKELPPNG PFCLLQEDVT LNMRVRLNVG FQEDLMNTSS ALYRSYKTDL ETAFRKGYGI LPGFKGVTVT GFKSGSVVVT YEVKTTPPSL ELIHKANEQV VQSLNQTYKM DYNSFQAVTI NESNFFVTPE IIFEGDTVSL VCEKEVLSSN VSWRYEEQQL EIQNSSRFSI YTALFNNMTS VSKLTIHNIT PGDAGEYVC (33-350 aa encoded by BC066121)
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR116 (G protein-coupled receptor 116) is a 1,346 amino acid multi-pass membrane protein that contains one SEA domain, one GPS domain and three Ig-like domains and belongs to the GPR family. Existing as a dilsulfide-liked homodimer at the cell surface, GPR116 exists as multiple alternatively spliced isoforms and is thought to play a role in regulating and maintaining proper acid-base balance throughout the cell.
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Protein Aliases: Adhesion G protein-coupled receptor F5; DKFZp564O1923; FLJ90640; G protein-coupled receptor 116; G-protein coupled receptor 116; Ig-Hepta homolog; probable G-protein coupled receptor 116
Gene Aliases: ADGRF5; GPR116; KIAA0758; KPG_001
UniProt ID: (Human) Q8IZF2
Entrez Gene ID: (Human) 221395
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