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Product Details
PA5-99633
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRB10(Accession Q13322), corresponding to amino acid residues N406-L456.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818566
Product Specific Information
Antibody detects endogenous levels of total GRB10.
Target Information
GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GRB10 adapter protein; GRB10 adaptor protein; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; maternally expressed gene 1; OTTHUMP00000197988; OTTHUMP00000197989; OTTHUMP00000197990; OTTHUMP00000197991; OTTHUMP00000197993; OTTHUMP00000197994
Gene Aliases: Grb-10; GRB-IR; GRB10; GRBIR; IRBP; KIAA0207; MEG1; RSS
UniProt ID: (Human) Q13322
Entrez Gene ID: (Human) 2887
negative regulation of Wnt signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of phosphorylation
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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