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Immunogen sequence: LQMFLSSST YPEIHGFLHA KEQGKKSWKK IYFFLRRSGL YFSTKGTSKE PRHLQFFSEF GNSDIYVSLA GKKKHGAPTN YGFCFKPNKA GGPRDLKMLC AEEEQSRTCW VTAIRLLKYG MQLYQNYMHP YQGRSGCSSQ SISPMRSISE NSLVAMDFSG QKSRVIENPT EALSVAVEEG LAWRKKGCLR LGTHGSPTAS SQSSATNMAI HRSQPWFHHK ISRDEAQRLI IQQGLVDGVF LVRDSQSNPK TFVLSMSHGQ KIKHFQIIPV EDDGEMFHTL DDGHTRFTDL IQLVEFYQLN KGVLPCKLKH YCARIAL (225-540 aa encoded by BC053559 )
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GRB14 adapter protein; Growth factor receptor-bound protein 14
Gene Aliases: AI505286; GRB14
UniProt ID: (Human) Q14449, (Mouse) Q9JLM9, (Rat) O88900
Entrez Gene ID: (Human) 2888, (Mouse) 50915, (Rat) 58844
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