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Product Details
H00002898-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRIK2 (AAH63814.1, 1 a.a. approximately 583 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IAR
Target Information
Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GluK2; GLUR 6; GluR-6; glutamate receptor; Glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 2; GRIK 2; GRIK2 protein
Gene Aliases: EAA4; GLR6; GluK2; GLUK6; GLUR6; GRIK2; MRT6
UniProt ID: (Human) Q13002
Entrez Gene ID: (Human) 2898
behavioral fear response
transport
cellular calcium ion homeostasis
intracellular protein transport
glutamate receptor signaling pathway
chemical synaptic transmission
neuronal action potential
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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