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The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: glutamate receptor; glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 4; mGluR4
Gene Aliases: GPRC1D; GRM4; mGlu4; MGLUR4
UniProt ID: (Human) Q14833
Entrez Gene ID: (Human) 2914
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