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            • Primary Antibodies ›
            • GSK3B Antibodies

            Invitrogen

            GSK3B Monoclonal Antibody (ZG004)

            Advanced Verification
            3 Published Figures
            3 References
            View all (87) GSK3B antibodies
            Datasheet
            Protocols
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            Tech Support
            Catalog # 39-9500
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            Price (EUR)
            385,65
            Online Exclusive
            514,00
            Save 128,35 (25%)
            100 µg
             
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            Datasheet
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            Cite GSK3B Monoclonal Antibody (ZG004)

            • Antibody Testing Data (3)
            • Published Figures (3)
            • Advanced Verification (2)
            Application
            GSK3B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 8

            GSK3B Antibody (39-9500) in IHC (P)

            Immunohistochemistry analysis of GSK3 Beta showing staining in the cytoplasm of paraffin-embedded human brain tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature,... View More
            View Product

            GSK3B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            GSK3B Antibody in Western Blot (WB)
            GSK3B Antibody in Western Blot (WB)
            GSK3B Antibody in Western Blot (WB)
            GSK3B Antibody in Western Blot (WB)
            GSK3B Antibody in Western Blot (WB)
            GSK3B Antibody
            GSK3B Antibody

            Product Details

            39-9500

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:250
            View 2 publications 2 publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1:10-1:100
            -

            Immunocytochemistry (ICC/IF)

            -
            View 1 publication 1 publication

            ELISA (ELISA)

            Assay-dependent
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Published species

            Human, Mouse

            Host/Isotype

            Mouse / IgG1, kappa

            Class

            Monoclonal

            Type

            Antibody

            Clone

            ZG004

            Immunogen

            Human GSK3 beta

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS

            Contains

            0.1% sodium azide

            Storage conditions

            -20°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2533442

            Target Information

            GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Related Products for

            Bioinformatics

            Protein Aliases: EC 2.7.11.26; FA; Factor A; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3beta isoform; pp37; Serine/threonine-protein kinase GSK3B

            View more View less

            Gene Aliases: 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3; GSK3B

            View more View less

            UniProt ID: (Human) P49841, (Mouse) Q9WV60, (Rat) P18266

            View more View less

            Entrez Gene ID: (Human) 2932, (Mouse) 56637, (Rat) 84027

            View more View less

            Function(s)

            RNA polymerase II transcription factor binding p53 binding protein kinase activity protein serine/threonine kinase activity integrin binding protein binding ATP binding beta-catenin binding kinase activity protein kinase binding ubiquitin protein ligase binding protein kinase A catalytic subunit binding ionotropic glutamate receptor binding tau protein binding tau-protein kinase activity NF-kappaB binding nucleotide binding transcription factor binding transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

            Process(es)

            re-entry into mitotic cell cycle epithelial to mesenchymal transition positive regulation of cell-matrix adhesion glycogen metabolic process regulation of gene expression by genetic imprinting protein phosphorylation protein export from nucleus ER overload response dopamine receptor signaling pathway axonogenesis myoblast fusion aging circadian rhythm organ morphogenesis negative regulation of cardiac muscle hypertrophy positive regulation of peptidyl-threonine phosphorylation positive regulation of mitochondrial membrane potential negative regulation of neuron maturation response to activity Wnt signaling pathway cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation hippocampus development establishment of cell polarity negative regulation of protein complex assembly positive regulation of protein complex assembly negative regulation of protein binding positive regulation of protein binding response to estradiol positive regulation of proteasomal ubiquitin-dependent protein catabolic process response to insulin regulation of microtubule-based process positive regulation of peptidyl-serine phosphorylation negative regulation of smooth muscle cell apoptotic process protein localization to microtubule intracellular signal transduction cellular response to hepatocyte growth factor stimulus cellular response to interleukin-3 cellular response to erythropoietin response to drug negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAP kinase activity positive regulation of neuron apoptotic process positive regulation of GTPase activity hypermethylation of CpG island canonical Wnt signaling pathway involved in positive regulation of apoptotic process fat cell differentiation negative regulation of glycogen biosynthetic process positive regulation of protein catabolic process positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of protein export from nucleus regulation of neuronal synaptic plasticity positive regulation of smooth muscle cell proliferation negative regulation of dendrite morphogenesis negative regulation of nitric-oxide synthase activity negative regulation of NFAT protein import into nucleus canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hydrogen peroxide superior temporal gyrus development cellular response to mechanical stimulus cellular response to iron(II) ion cellular response to lithium ion response to epinephrine negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway in absence of ligand chemical synaptic transmission, postsynaptic regulation of cellular response to heat negative regulation of protein localization to nucleus positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of neuron death response to L-glutamate cellular response to dopamine negative regulation of dopaminergic neuron differentiation beta-catenin destruction complex assembly beta-catenin destruction complex disassembly response to insulin-like growth factor stimulus response to ultrasound response to angiotensin negative regulation of type B pancreatic cell development positive regulation of excitatory postsynaptic potential negative regulation of glycogen (starch) synthase activity positive regulation of DNA biosynthetic process positive regulation of stem cell differentiation negative regulation of neuron migration carbohydrate metabolic process cytoskeleton organization establishment or maintenance of cell polarity multicellular organism development nervous system development cell proliferation negative regulation of signal transduction regulation of neuron projection development negative regulation of neuron projection development myotube differentiation phosphorylation cell differentiation positive regulation of apoptotic process rhythmic process response to lithium ion
            It has to be done as per old AB suggested Products section.
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