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Invitrogen
Glypican 2 Polyclonal Antibody
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Application
FIGURE: 1 / 3
Glypican 2 Antibody (PA5-115299) in ICC/IF
Immunocytochemistry analysis of Glypican 2 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115299). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) a... View More
Product Details
PA5-115299
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GPC2(Accession Q8N158), corresponding to amino acid residues Y134-F184.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899935
Product Specific Information
Antibody detects endogenous levels of total Glypican 2.
Target Information
Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cerebroglycan; cerebroglycan proteoglycan; glypican proteoglycan 2, cerebroglycan proteoglycan; Glypican-2; HSPG M13
Gene Aliases: 2410016G05Rik; GPC2
UniProt ID: (Human) Q8N158, (Rat) P51653, (Mouse) Q8BKV1
Entrez Gene ID: (Human) 221914, (Rat) 171517, (Mouse) 71951
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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