Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: RSSCEVVSK ANCAKLKQGI AVRFHGEEGM GQGVVREWFD ILSNEIVNPD YALFTQSADG TTFQPNSNSY VNPDHLNYFR FAGQILGLAL NHRQLVNIYF TRSFYKHILG IPVNYQDVAS IDPEYAKNLQ WILDNDISDL GLELTFSVET DVFGAMEEVP LKPGGGSILV TQNNKAEYVQ LVTELRMTRA IQPQINAFLQ GFHMFIPPSL IQLFDEYELE LLLSGMPEID VSDWIKNTEY TSGYEREDPV IQWFWEVVED ITQEERVLLL QFVTGSSRVP HGGFANIMGG SGLQNFTIAA VPYTPNLLPT SSTCINMLKL PEYPSKEILK DRLLVALHCG SYGYTMA (564-909 aa encoded by BC034982 )
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase HACE1; hace 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
Gene Aliases: HACE1; KIAA1320; SPPRS
UniProt ID: (Human) Q8IYU2
Entrez Gene ID: (Human) 57531
Molecular Function: ubiquitin-protein ligase
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