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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ankyrin repeat domain 32; Ankyrin repeat domain-containing protein 32; BRCT domain containing 1; BRCT domain-containing protein 1; SMC5-SMC6 complex localization factor protein 1; Smc5/6 localization factor 1
Gene Aliases: ANKRD32; BRCTD1; BRCTx; SLF1
UniProt ID: (Human) Q9BQI6
Entrez Gene ID: (Human) 84250
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