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Application
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HAPLN4 Antibody (MA5-23313) in ELISA
Detection limit for recombinant GST tagged HAPLN4 using anti-HAPLN4 monoclonal antibody (Product # MA5-23313) is 1 ng/mL as a capture antibody.
Product Details
MA5-23313
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1C1
Immunogen
HAPLN4 (NP_075378, 30 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2-1.0 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606992
Product Specific Information
Peptide Sequence: QRGRKKVVHV LEGESGSVVV QTAPGQVVSH RGGTIVLPCR YHYEAAAHGH DGVRLKWTKV VDPLAFTDVF VALGPQHRAF GSYRGRAELQ GDGPGDASLV LRNVT
Target Information
Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain link protein 2; Hyaluronan and proteoglycan link protein 4
Gene Aliases: BRAL2; HAPLN4; KIAA1926
UniProt ID: (Human) Q86UW8
Entrez Gene ID: (Human) 404037
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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