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The C-terminus of BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: BTB (POZ) domain containing 1; BTB/POZ domain-containing protein 1; HCV NS5A-transactivated protein 8; Hepatitis C virus NS5A-transactivated protein 8
Gene Aliases: BTBD1; C15orf1; NS5ATP8
UniProt ID: (Human) Q9H0C5
Entrez Gene ID: (Human) 53339
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