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            • Primary Antibodies ›
            • HENMT1 Antibodies

            Invitrogen

            HENMT1 Polyclonal Antibody

            2 Published Figures
            1 Reference
            View all (3) HENMT1 antibodies
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            Datasheet
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            Cite HENMT1 Polyclonal Antibody

            • Antibody Testing Data (5)
            • Published Figures (2)
            Application
            HENMT1 Antibody in Immunohistochemistry (IHC)
            Group 53 Created with Sketch.

            FIGURE: 1 / 7

            HENMT1 Antibody (PA5-55866) in IHC

            Immunohistochemical staining of HENMT1 in human testis using HENMT1 Polyclonal Antibody (Product # PA5-55866) shows moderate to strong nuclear and cytoplasmic positivity in cells in seminiferous ducts.
            View Product

            HENMT1 Antibody in Immunohistochemistry (IHC)
            HENMT1 Antibody in Immunohistochemistry (IHC)
            HENMT1 Antibody in Immunohistochemistry (IHC)
            HENMT1 Antibody in Immunohistochemistry (IHC)
            HENMT1 Antibody in Western Blot (WB)
            HENMT1 Antibody in Immunohistochemistry (IHC)
            HENMT1 Antibody in Immunohistochemistry (IHC)

            Product Details

            PA5-55866

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.04-0.4 µg/mL
            -

            Immunohistochemistry (IHC)

            -
            View 1 publication 1 publication

            Immunohistochemistry (Paraffin) (IHC (P))

            1:50-1:200
            -
            Product Specifications

            Species Reactivity

            Human

            Published species

            Mouse

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Recombinant protein corresponding to Human HENMT1. Recombinant protein control fragment (Product #RP-94398).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.2, with 40% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2642389

            Product Specific Information

            Immunogen sequence: MEENNLQCSS VVDGNFEEVP RETAIQFKPP LYRQRYQFVK NLVDQHEPKK VADLGCGDTS LLRLLKVNPC IELLVGV

            Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 47%.

            Target Information

            HENMT1 (HEN Methyltransferase 1) is a small RNA methyltransferase gene crucial for the stability and functionality of PIWI-interacting RNAs (piRNAs). It is located in human chromosome 1 at the p36.31 locus. The HENMT1 protein catalyzes the 2'-O-methylation at the 3' end of piRNAs in a Mg2+ dependent manner. This modification is essential for piRNA maturation and stability, ensuring the repression of transposable elements (TEs) during spermatogenesis and maintaining genomic integrity in male germ cells. Studies have highlighted the impact of HENMT1 mutations causing male infertility due to disrupted piRNA pathway and improper germ cell gene regulation. The enzymatic activity of HENMT1 is not only significant for male fertility but is also involved in maintaining piRNA stability in female germ cells, although females with HENMT1 mutations show subfertility.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: HEN1 methyltransferase homolog 1; hua enhancer 1 homolog 1; Small RNA 2'-O-methyltransferase

            View more View less

            Gene Aliases: C1orf59; HEN1; HENMT1

            View more View less

            UniProt ID: (Human) Q5T8I9

            View more View less

            Entrez Gene ID: (Human) 113802

            View more View less

            Function(s)

            RNA binding protein binding O-methyltransferase activity RNA methyltransferase activity metal ion binding

            Process(es)

            RNA methylation gene silencing by RNA piRNA metabolic process
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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