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Immunogen sequence: MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWG
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: HECT domain and RCC1-like domain-containing protein 3; hect domain and RLD 3; HECT-type E3 ubiquitin transferase HERC3; Probable E3 ubiquitin-protein ligase HERC3
Gene Aliases: HERC3; KIAA0032
UniProt ID: (Human) Q15034
Entrez Gene ID: (Human) 8916
Molecular Function: ubiquitin-protein ligase
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