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Application
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HES4 Antibody (PA5-41167) in WB
Western blot analysis of transfected 293T cells using an anti-HES-4 polyclonal antibody (Product # PA5-41167).
Product Details
PA5-41167
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human HES4 (aa 1-50).
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2577190
Product Specific Information
Peptide sequence: MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI
Sequence homology: Cow: 86%; Dog: 93%; Human: 100%; Pig: 85%; Rat: 77%
Target Information
HES4, or Hes Family BHLH Transcription Factor 4, is a gene located on chromosome 1p36.31, encoding a basic helix-loop-helix (bHLH) transcription factor that plays a role in the Notch signaling pathway. This pathway is integral to cell differentiation, proliferation, and apoptotic processes, especially during embryonic development and tissue homeostasis. HES4 acts as a transcriptional repressor, regulating the expression of genes responsible for maintaining stem cell populations and inhibiting premature differentiation. While its exact biological roles are still being elucidated, studies suggest HES4 influences neurogenesis and myogenesis by modulating the timing of differentiation events within progenitor cells. The dysregulation of HES4 can impact normal developmental processes, potentially contributing to pathologies such as cancer and developmental disorders due to its control over cellular growth and differentiation pathways. Research into HES4 continues to advance understanding of its functions within the context of Notch signaling and its implications for disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH factor Hes4; bHLHb42; Class B basic helix-loop-helix protein 42; Hairy and enhancer of split 4; hHES4; Transcription factor HES-4
Gene Aliases: BHLHB42; HES4
UniProt ID: (Human) Q9HCC6
Entrez Gene ID: (Human) 57801
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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