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HFE2 Antibody (TA809327) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HFE2 (RC220228, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-HFE2. (1:2000)
Product Details
TA809327
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI3H2
Immunogen
Human recombinant protein fragment corresponding to amino acids 36-263 of human HFE2 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DL M; haemojuvelin; HEMOCHROMATOSIS; Hemochromatosis type 2 protein; Hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C
Gene Aliases: HFE2; HFE2A; HJV; JH; RGMC
UniProt ID: (Human) Q6ZVN8
Entrez Gene ID: (Human) 148738
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
protein autoprocessing
BMP signaling pathway
negative regulation of BMP signaling pathway
activin receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
cellular response to BMP stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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