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Invitrogen
HIRA Polyclonal Antibody
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Product Details
PA5-65749
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human HIRA. Recombinant protein control fragment (Product #RP-106426).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2662971
Product Specific Information
Immunogen sequence: TWNLVSDKQDS LAQCADFRSS LPSQDAMLCS GPLAIIQGRT SNSGRQAARL FSVPHVVQQE TTLAYLENQV AAALTLQSSH EYRHWLLVYA RYLVNEGFEY RLREICKDLL GPVHYSTG
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 95%.
Target Information
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DiGeorge critical region gene 1; HIR histone cell cycle regulation defective homolog A; Protein HIRA; TUP1-like enhancer of split protein 1
Gene Aliases: DGCR1; HIR; HIRA; TUP1; TUPLE1
UniProt ID: (Human) P54198
Entrez Gene ID: (Human) 7290
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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