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Predicted to react with rat, mouse, bovine and chicken based on sequence homology.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H2A-clustered histone 21; histone 2, H2ab; Histone H2A type 2-B
Gene Aliases: H2AB; H2AC21; HIST2H2AB
UniProt ID: (Human) Q8IUE6
Entrez Gene ID: (Human) 317772
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