Proteintech

HMGCR Polyclonal Antibody

HMGCR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HMGCR Antibody (13533-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 13533-1-AP) (HMGCR antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

13533-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 30 publications 30 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HMGCR Fusion Protein Ag4444 (588-888 aa encoded by BC033692)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TRGPVVRLP RACDSAEVKA WLETSEGFAV IKEAFDSTSR FARLQKLHTS IAGRNLYIRF QSRSGDAMGM NMISKGTEKA LSKLHEYFPE MQILAVSGNY CTDKKPAAIN WIEGRGKSVV CEAVIPAKVV REVLKTTTEA MIEVNINKNL VGSAMAGSIG GYNAHAANIV TAIYIACGQD AAQNVGSSNC ITLMEASGPT NEDLYISCTM PSIEIGTVGG GTNLLPQQAC LQMLGVQGAC KDNPGENARQ LARIVCGTVM AGELSLMAAL AAGHLVKSHM IHNRSKINLQ DLQGACTKKT A (588-888 aa encoded by BC033692)

Target Information

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269

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Gene Aliases: 3H3M; HMG-CoAR; HMGCR; LDLCQ3; Red

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UniProt ID: (Human) P04035, (Mouse) Q01237, (Rat) P51639

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Entrez Gene ID: (Human) 3156, (Mouse) 15357, (Rat) 25675

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Function(s)

hydroxymethylglutaryl-CoA reductase (NADPH) activity protein binding hydroxymethylglutaryl-CoA reductase activity protein homodimerization activity coenzyme binding protein phosphatase 2A binding NADPH binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NADP binding oxidoreductase reductase metabolite interconversion enzyme

Process(es)

cholesterol biosynthetic process ubiquinone metabolic process aging response to nutrient isoprenoid biosynthetic process visual learning negative regulation of striated muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process coenzyme A metabolic process positive regulation of stress-activated MAPK cascade negative regulation of MAP kinase activity myoblast differentiation response to ethanol negative regulation of vasodilation positive regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation protein tetramerization oxidation-reduction process negative regulation of wound healing negative regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of ERK1 and ERK2 cascade lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation embryo development sterol biosynthetic process negative regulation of apoptotic process farnesyl diphosphate biosynthetic process, mevalonate pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HMGCR Polyclonal Antibody

HMGCR Antibody (13533-1-AP) in IHC (P)

Product Details

13533-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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