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HNF-3 alpha / FOXA1 Monoclonal Antibody (2F83)

View all (51) FOXA1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)

Application

HNF-3 alpha / FOXA1 Antibody in Western Blot (WB)

FIGURE: 1 / 2

HNF-3 alpha / FOXA1 Antibody (39837) in WB

HNF-3alpha / FOXA1 antibody (mAb) tested by Western blot. Extract of HeLa cells over-expressing mouse HNF-3alpha / FOXA1 (50 µg per lane) probed with HNF-3beta / FOXA1 antibody (mAb) (1:5,000 dilution).

HNF-3 alpha / FOXA1 Antibody in ChIP-Sequencing (ChIP-Seq)

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Product Details

39837

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

ChIP assay (ChIP)

5-10 µg

ChIP-sequencing (ChIP-Seq)

5-10 µg

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

2F83

Immunogen

This HNF-3 alpha / FOXA1 antibody was raised against a recombinant protein corresponding to amino acids 7-103 of rat HNF-3 alpha /FOXA1.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

70mM tris, pH 8, with 31mM glycine, 30% glycerol, 105mM NaCl, 0.07mM EDTA

Contains

0.035% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2793362

Target Information

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ci-fkh; fkd7; fkh; fork head domain; Forkhead box protein A1; forkhead-7; FoxA4a; hepatocyte nuclear factor 3 alpha (winged helix transcription factor); Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; tFoxA1; Transcription factor 3A; xfkh1; xfkh2

Gene Aliases: FOXA1; Hnf-3a; HNF3A; Tcf-3a; TCF3A

UniProt ID: (Human) P55317, (Mouse) P35582

Entrez Gene ID: (Human) 3169, (Mouse) 15375

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding sequence-specific DNA binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding winged helix/forkhead transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter chromatin remodeling transcription from RNA polymerase II promoter Notch signaling pathway negative regulation of epithelial to mesenchymal transition covalent chromatin modification dorsal/ventral neural tube patterning response to estradiol positive regulation of intracellular estrogen receptor signaling pathway hormone metabolic process glucose homeostasis positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis neuron fate specification positive regulation of sequence-specific DNA binding transcription factor activity epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development epithelial-mesenchymal signaling involved in prostate gland development prostate gland epithelium morphogenesis prostate gland stromal morphogenesis epithelial cell maturation involved in prostate gland development alveolar secondary septum development dopaminergic neuron differentiation respiratory basal cell differentiation positive regulation of cell-cell adhesion mediated by cadherin transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development regulation of gene expression chromatin modification lung development tube morphogenesis regulation of cell cycle connective tissue development

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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