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Immunogen sequence: YGTAKGYGS GGGGAQQLGA GPFPAQPPGR GFDLPPALAS GSADAARKER ALDSPPPPTL ACGSGGGSQG DEEAHASSSA AEELSPAPSE SSKASPEKDS LGNSKGENAA (203-311 aa encoded by BC013971)
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factorm HOXA10, that may regulate gene expression, morphogenesis, and differentiation. More specifically, HOXA10 may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 gene.
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Protein Aliases: homeo box A10; homeobox protein 1H; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; Homeobox protein Hox-A10; homeobox protein HOXA10; Hox-18; PL
Gene Aliases: HOX1; HOX1.8; HOX1H; HOXA10; PL
UniProt ID: (Human) P31260
Entrez Gene ID: (Human) 3206
Molecular Function: helix-turn-helix transcription factor homeodomain transcription factor DNA-binding transcription factor gene-specific transcriptional regulator
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