Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive Samples: 293T, K-562
Immunogen sequence: MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG
HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
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Protein Aliases: homeo box 2F; homeo box B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; Homeobox protein Hox-B4
Gene Aliases: HOX-2.6; HOX2; HOX2F; Hoxb-4; HOXB4; RGD1560113
UniProt ID: (Human) P17483, (Mouse) P10284
Entrez Gene ID: (Human) 3214, (Rat) 497988, (Mouse) 15412
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