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Product Details
PA5-33846
Product Specifications
Species Reactivity
Bovine,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from 2nd cytoplasmic domain of human HRH3 / Histamine H3 Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551215
Product Specific Information
This antibody is not recommended for use in WB applications.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Bovine, Horse, Guinea pig (100%).
Target Information
H3 Histamine Receptor regulates the release of the neurotransmitters norepinephrine and somatostatin. In histamine-containing neurons of the brain, the H3 receptor acts as a presynaptic autoreceptor, while in nonhistamine-containing neurons, in both the central and peripheral nervous systems, it acts as a presynaptic heteroreceptor. Multiple isoforms of H3 receptors are produced by alternative splicing. Histamine H3 receptor has been reported primarily in brain. ESTs have been isolated from brain (normal and cancer), breast cancer, colon cancer, and retinoblastoma libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor 97; G-protein coupled receptor 97; H3R; HH3R; Histamine H3 receptor; histamine H3 receptor H3L isoform; histamine receptor; histamine receptor H 3; histamine receptor H3
Gene Aliases: AW049250; GPCR97; H3R; HH3R; HRH3; I79_009854
UniProt ID: (Human) Q9Y5N1, (Rat) Q9QYN8, (Guinea pig) Q9JI35, (Mouse) P58406
Entrez Gene ID: (Horse) 100058016, (Human) 11255, (Rat) 85268, (Guinea pig) 100135541, (Chinese hamster) 100764853, (Mouse) 99296
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
neurotransmitter secretion
synaptic transmission, cholinergic
negative regulation of glutamate secretion
regulation of norepinephrine secretion
negative regulation of serotonin secretion
cognition
regulation of neurotransmitter levels
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
brain development
learning
memory
negative regulation of gamma-aminobutyric acid secretion
response to organic cyclic compound
eating behavior
drinking behavior
negative regulation of blood pressure
positive regulation of epithelial cell proliferation
signal transduction
sensory perception of chemical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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