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Product Details
PA5-33851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 17 amino acid peptide from C-terminus of human HRH4 / Histamine H4 Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551220
Product Specific Information
Percent identity with other species by BLAST analysis: Human (100%) Gibbon, Monkey (94%).
Target Information
The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AXOR35; G-protein coupled receptor 105; Gprc105; GPRv53; H4R; Histamine H4 receptor; histamine receptor; MGC130500; Pfi-013; SP9144
Gene Aliases: AXOR35; BG26; GPCR105; GPRv53; H4; H4R; HH4R; HRH4
UniProt ID: (Human) Q9H3N8
Entrez Gene ID: (Human) 59340
inflammatory response
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
biological_process
regulation of MAPK cascade
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