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FIGURE: 1 / 3
HSPB8 Antibody (MA5-53188) in ICC/IF
Immunocytochemistry analysis of HSPB8 in HepG2 cells. Nuclei were stained blue with DAPI; HSPB8 recombinant monoclonal antibody (Product # MA5-53188) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-53188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB1980
Immunogen
A synthesized peptide derived from human HSPB8/HSP22 (5-32AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-crystallin C chain; DHMN 2; E2-induced gene 1 protein; heat shock 22kDa protein 8; heat shock 27kDa protein 8; Heat shock protein; Heat shock protein beta-8; Heat shock protein family B member 8; HMN 2; HSB8; HSP; HSPB 8; HspB8; OTTHUMP00000239768; Protein kinase H11; Small stress protein-like protein HSP22
Gene Aliases: AU018630; AW413033; CMT2L; CRYAC; D5Ucla4; DHMN2; E2IG1; H11; H11K; HMN2; HMN2A; HSP20-like; HSP22; HSPB8; PP1629
UniProt ID: (Human) Q9UJY1, (Mouse) Q9JK92
Entrez Gene ID: (Human) 26353, (Mouse) 80888
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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